Promiscuous drug

The question, Can we rationally design promiscuous drugs was discussed in a recent paper by Hopkins tt al. [5]. Different views of the data linking structural... 

Hopkins, A.L. Mason, J.S. and Overington, J.P. (2006) Can we rationally design promiscuous drugs Current Opinion in Structural Biology, 16,127—136. 

Stephenson, V.C., Heydingb, R.A. and Weaver, D.F. (2005) The promiscuous drug concept with applications to Alzheimer s disease. FEES letters, 579 (6), 1338-1342. 

Mencher, S.K. and Wang, L.G. (2005) Promiscuous drugs compared to selective drugs (promiscuity can be a virtue). BMC Clinical Pharmacology, 5 (1), 3-13. 

In any case, it is easy to understand how something like membrane stabilization could help neurons be more temperate, and how a more temperate brain could more easily resist its own tendency to go wild. In clinical terms this means that such indulgences as flights of ideas, pressured speech, buying sprees, sexual promiscuity, drug taking, and manic psychosis will be less likely. 

Hopkins, A. L., et al., Can we rationally design promiscuous drugs , Curr Opin Struct Biol, 2006, 16, 127-136. 

Recent analysis suggests that targets of promiscuous drugs cannot necessarily be similar to each other (2, 7), meaning that... 

Is There Really a Case for Promiscuous Drugs in Anticancer Therapy ... 

The correlation between promiscuity in a safety profiling panel and side effect outcome for a particular drug is very high (7). Until a rational design of promiscuous drugs with desired features becomes possible (8), the main paradigm for drug discovery remains to create compounds that are as selective as possible... 

Figure 8.5 BioPrint cluster analysis of 2000 compounds and drugs across 70 pharmacological assays (pICsos). Biological assays are on the x-axis, clustered by similarity, and compounds on they-axis, clustered by their fingerprint of biological activity. Red indicates most active and blue indicates inactive (Reprinted with permission from, Hopkins, et al. Can we rationally design promiscuous drugs Curr. Opin. Struct. Biol., 16, 127-136, copyright 2006, Elsevier.)...

Stephenson, V. C., Heyding, R. A., Weaver, D. F. The promiscuous drug concept with appUcations to Alzheimer s disease. FEBS Lett. 2005, 579,1338-1342. 

Ma Q, Lu AY. The challenges of dealing with promiscuous drug-metabolizing enzymes, receptors and transporters. Curr Drug Metab 2008 9(5) 374-383. 

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