Big Chemical Encyclopedia

Chemical substances, components, reactions, process design ...

Articles Figures Tables About

Drugs clozapine

Kaiser etal. (2000) DRD4 (48-bp repeat) Typical antipsychotic drugs, clozapine No association. Schizophrenia Caucasian... [Pg.73]

Figure 12.1 Cost of atypical antipsychotic drugs (clozapine and risperidone) in each country/territory for patients with schizophrenia... Figure 12.1 Cost of atypical antipsychotic drugs (clozapine and risperidone) in each country/territory for patients with schizophrenia...
Despite their importance in psychiatry, the neuroleptics are by no means cure-alls. Even patients that respond extremely well to neuroleptics remain disturbed. Specifically, though their florid hallucinations and delusions, the positive symptoms of schizophrenia, are alleviated, patients remain emotionally detached from the environment. This wallflower syndrome and related symptoms are commonly designated the negative symptoms of schizophrenia and often are the most disabling ones. The first glimmer of effective treatment of such negative symptoms came with the drug clozapine. [Pg.79]

Another serious side effect of clozapine is a risk of seizures. This mainly occurs at higher doses of the drug, and having a seizure is not necessarily a sufficient reason to stop clozapine permanently. If the clozapine has been especially helpful, an anticonvulsant can be added to protect against further seizures. Valproate (Depakote) may be best in this regard because it not only provides protection from seizures but also may help to relieve some of the symptoms of schizophrenia. Recently, it has become clear that two atypical antipsychotic drugs, clozapine and olanzapine, are associated with an increased risk for the development of type II diabetes. [Pg.117]

Adverse event/Drug Clozapine Olanzapine Quetiapine... [Pg.310]

A 17-year-old boy with severe clozapine-induced neutropenia had a negative rechallenge because he had had an unsatisfactory response to traditional neuroleptic drugs, clozapine was continued despite a fall in white blood cell count, since concomitant treatment with granulocyte colony-stimulating factor was followed by rapid normalization of the white blood cell count (152). [Pg.272]

ANTIPSYCHOTIC DRUGS -CLOZAPINE SELENIUM 4 selenium levels Uncertain Be aware... [Pg.740]

There is some evidence that the atypical neuroleptic drug clozapine can alleviate levodopa-induced dyskinesia while itself providing additional relief in Parkinson s disease (SEDA-18, 159) clozapine may also relieve levodopa-induced psychosis (SEDA-17,166). [Pg.2041]

Other antipsychotic drugs (clozapine) Blunting of T waves ST segment depression ... [Pg.469]

Among these drugs, clozapine, aripiprazole, and PD 158771 can decrease dopamine and serotonin synthesis in the neostriatum, and most of these drugs share a similar behav-... [Pg.652]

A difference in the in vitro activities may sometimes be desirable where a different level of receptor occupancy for each target is associated with a desired pharmacological effect. The atypical profile of the anti-psychotic drug, clozapine, has been variously associated with its lower activity at the D4 or 5-HT2A receptors compared to the... [Pg.564]

Ashby CR Jr, Wang RY. Pharmacological actions of the atypical antipsychotic drug clozapine A review. Synapse 1996 24 349-394. [Pg.89]

Fig. 3. Simple interaction network for the drug clozapine, three P450 enzymes for which clozapine is a substrate, the enzymatic clozapine metabolic reaction catalyzed by the enzymes, and the clozapine metabolite resulting from the reaction. Compound-protein and compound-reaction interactions are shown. Compounds are represented by hexagons, proteins by different solid shapes representing different classes of compound, and enzymatic reactions by rectangles. Edges (interactions) between nodes (network objects) are shown as unidirectional arrows with a mechanism of interaction represented by letters in hexagonal boxes over the arrows (6 binding, Zcatalysis). Fig. 3. Simple interaction network for the drug clozapine, three P450 enzymes for which clozapine is a substrate, the enzymatic clozapine metabolic reaction catalyzed by the enzymes, and the clozapine metabolite resulting from the reaction. Compound-protein and compound-reaction interactions are shown. Compounds are represented by hexagons, proteins by different solid shapes representing different classes of compound, and enzymatic reactions by rectangles. Edges (interactions) between nodes (network objects) are shown as unidirectional arrows with a mechanism of interaction represented by letters in hexagonal boxes over the arrows (6 binding, Zcatalysis).
Two other cloned receptors, 5-HT and 5-HTy, are linked to activation of adenylyl cyclase. Multiple splice variants of the 5-HTj receptor have been found, although functional distinctions are not clear. Circumstantial evidence suggests that 5-HT receptors play a role in smooth-muscle relaxation in the GI tract and the vasculature. The atypical antipsychotic drug clozapine has a high... [Pg.191]

Atypical Antipsychotic Drugs Clozapine (clozaril), a receptor antagonist, repre-... [Pg.200]


See other pages where Drugs clozapine is mentioned: [Pg.591]    [Pg.374]    [Pg.220]    [Pg.146]    [Pg.411]    [Pg.283]    [Pg.400]    [Pg.232]    [Pg.631]    [Pg.637]    [Pg.238]    [Pg.286]    [Pg.146]    [Pg.271]    [Pg.176]    [Pg.186]    [Pg.6]    [Pg.308]    [Pg.272]    [Pg.451]    [Pg.217]    [Pg.681]    [Pg.591]    [Pg.2043]    [Pg.2462]    [Pg.372]    [Pg.551]    [Pg.241]    [Pg.164]    [Pg.105]    [Pg.294]    [Pg.460]    [Pg.339]    [Pg.474]   
See also in sourсe #XX -- [ Pg.966 ]




SEARCH



Antipsychotic drugs clozapine

Clozapin

Clozapine

Clozapine adverse drug reactions

Clozapine drug administration

Clozapine drug formulations

Clozapine drug interactions

Clozapine drug overdose

Clozapine drug withdrawal

Clozapine interaction with other drugs

Neuroleptic drugs clozapine

© 2024 chempedia.info