Clozapine drug formulations

ANTIPSYCHOTICS-PHENOTHIAZINE, CLOZAPINE, PIMOZIDE NITRATES 1. T risk of antimuscarinic side-effects when isosorbide dinitrate is co administered with these drugs. 2.1 efficacy of sublingual nitrate tablets 1. Additive effect both of these drugs cause antimuscarinic side-effects 2. Antimuscarinic effects i saliva production, which i dissolution of the tablet 1. Warn patient of these effects 2. Consider changing the formulation to a sublingual nitrate spray... 

Solid lipid nanoparticles were originally developed for parenteral drug delivery to provide a parenteral drug carrier system based on physiological compounds and a potential controlled release and/or targeting of the drug. A broad variety of drugs (e.g. doxorubicin, camptothecin, etoposide, mitoxan-trone, tamoxifen,paclitaxel, clozapine, lovastatin, bromocriptine, temozolomide, actarit and dexametha-sone °) has already been incorporated into SLN formulations and tested in vivo in mice or rat. 

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