Drugs chemical interaction

It is necessary to establish the safety of polymers by extensive animal and subsequent human testing. All Dolymers must pass Class VI U.S.P. tests for polymers in contact with drugs. Chemical interaction with the drug is ruled out and interaction with body lipids should be minimal to avoid shifts of permeability and loss of mechanical integrity vivo. 

Another important type of physical chemical interaction that may alter absorption is that of drug binding or adsorption onto the surface of another material. As with complexation and micellarization, adsorption will reduce the effective concentration gradient between gut fluids and the bloodstream, which is the driving force for passive absorption. While adsorption frequently reduces the rate of absorption, the interaction is often readily reversible and will not affect the extent of absorption. A major exception is adsorption onto charcoal, which in many cases appears to be irreversible, at least during the time of residence within the GIT. As a result, charcoal often reduces the extent of drug absorption. Indeed, this fact... 

Weinstein, H., R. Osman, and J. P. Green. 1979. The Molecular Basis of Structure-Activity Relationships Quantum Chemical Recognition Mechanisms in Drug-Receptor Interactions. In Computer-Assisted Drug Design. E. C. Olson and R. E. Christofferson, eds. American Chemical Society, Washington, D.C. 

The sample temperature is increased in a linear fashion, while the property in question is evaluated on a continuous basis. These methods are used to characterize compound purity, polymorphism, solvation, degradation, and excipient compatibility [41], Thermal analysis methods are normally used to monitor endothermic processes (melting, boiling, sublimation, vaporization, desolvation, solid-solid phase transitions, and chemical degradation) as well as exothermic processes (crystallization and oxidative decomposition). Thermal methods can be extremely useful in preformulation studies, since the carefully planned studies can be used to indicate the existence of possible drug-excipient interactions in a prototype formulation [7]. 

More than 200,000 infants are born with physical or mental damage each year. About 20% of all birth defects are believed strictly the result of environmental factors such as drugs, chemicals, or radiation, and another 60% are believed to be the result of an interaction of environmental and hereditary factors. 

Drug/food/chemical interactions which enhance action of drug/reduce clearance. Polypharmacy increases the chance of interactions. About 4—5% of prescription drugs used in hospital have the potential for interaction. About 7% of ADRs may be due to interaction, and up to 1% of hospital admissions are due to interaction. The more drugs, the more interactions are likely. With up to 5 drugs, the chance is about 4%. With 16-20 drugs the chance is up to 54%. 

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