Druggability

Set the task of discovering new, previously unknown druggable receptors, how would we go about it In particular, how would we find a GPCR The first step toward functional annotation of a new GPCR sequence usually involves searching a primary sequence database with pairwise similarity tools. Such searches can reveal clear similarities between the query sequence... 

An J, Totrov M, Abagyan R. Comprehensive identification of druggable protein ligand binding sides. Genome Informatics 2004 15 31-41. 

Today s drug targets are less druggable than in the past [23] the low-hanging fruit in the center of drug-like space has already been picked... 

The large majority of the studies undertaken to understand druggability from an assessment of either in vitro and or in silico physicochemical properties are aimed at the common goal of ameliorating the risk of... 

Hopkins, A.L. and Groom, C.R. (2002) The druggable genome. Nature Reviews Drug discovery, 1, 727-730. 

However, none of the above-mentioned databases are directly usable to generate a collection of druggable protein active sites customized to accommodate small molecular-weight drug-like ligands. Generally, no... 

Diversity of targets based on the concept of the druggable proteome and on phylogenetic analysis. 

Figure . A cross-section of the druggable proteome taken from Ref. 10. Proteins in dose proximity-in this dendrogram are members of the same gene famiiy and share sequence simiiarity and structure simiiarity in reguiatory and iigand-binding domains. 92 proteins that are part of the BioPrint in vitro pharmacoiogicai profiie are shown in pink and cover a representative portion of the druggabie proteome.

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