Druggable proteome

Diversity of targets based on the concept of the druggable proteome and on phylogenetic analysis. 

Figure . A cross-section of the druggable proteome taken from Ref. 10. Proteins in dose proximity-in this dendrogram are members of the same gene famiiy and share sequence simiiarity and structure simiiarity in reguiatory and iigand-binding domains. 92 proteins that are part of the BioPrint in vitro pharmacoiogicai profiie are shown in pink and cover a representative portion of the druggabie proteome.

The evolution of methods for combinatorial syntheses and high throughput screening will be necessary to address the explosion of druggable targets soon to be identified by the genomics and proteomics revolutions. Genomics and proteomics represent the future of lead compound identification. 

In addition to using a sequence homology approach, we also approached the problem of identifying the druggable subset of the human proteome using a feature-based Bayesian method. 

In Silico Literally in the computer. It can be used to screen out compounds which are not druggable. Narrower terms include in silico biology, in silico modeling, in silico proteomics, in silico screening, and so forth. 

---