Similarity tool

At the moment, most scientists and students, both in companies and at universities, use similar tools for the encoding processes described. But this was not the case in the past, when research was much more differentiated and fascinating with regard to the chemist-computer interaction. Some of these old-fashioned results are still impressive or some are still used, even now, as the following examples illustrate. 

Construet, on log-linear graph paper, using asymptotes, and validate using MATLAB or a similar tool, the Bode diagrams for... 

Set the task of discovering new, previously unknown druggable receptors, how would we go about it In particular, how would we find a GPCR The first step toward functional annotation of a new GPCR sequence usually involves searching a primary sequence database with pairwise similarity tools. Such searches can reveal clear similarities between the query sequence... 

Perhaps there are hidden in the symbolic limbo other possible similar tools, even better than these described here. We are confident in that this paper will stimulate the research interest in this direction. 

In conventional preparative TLC, after the separation the. bands are visualized and the separated zones carefully marked for removal. The zones are scraped off the plate with a spatula similar tool onto glassine weighing paper. A number of devices based on the vacuum suction principle are commercially available ... 

In chapter I it was shown how the handling of moments and cumulants was facilitated by the use of a moment generating function. A similar tool will now be introduced with respect to the / . Instead of the auxiliary variable k we now need an auxiliary function, or test function v(t and instead of a generating function we have therefore a functional, i.e., a quantity depending on all the values that v takes for — oo < t < oo (indicated by [v]). The generating functional for the / is... 

Another useful structure tool is RasMol (or RasMac). This will allow you to view the detailed structure of a protein and rotate it on coordinates so you can see it from all perspectives. A hyperlink to RasMol is present under the View Structure function just above Chime. You may need to study RasMol instructions provided under Help, or you may use a Ra.s Mol tutorial listed in Table El.2. Another useful protein viewer is tin-Swiss-Protein Pdv Viewer (Table El.2). BLAST is an advanced sequence similarity tool available at NCBI. To access this, go to the NCBI home page (www.ncbi.nlm.nih.gov) and click on BLAST. Then click on Basic BLAST search to obtain a dialogue box into which you may type the amino acid sequence of human a-lactalbumin. This process may be stream lined by downloading the amino acid sequence in FASTA format into a file and transferring the fde into the BLAST dialogue box. BLAST will provide a list of proteins with sequences similar to the one entered. 

A recent report presented the so-called MultiLevel Chemical Compatibility (MLCC) to determine the similarity of any structure to known drug-compatible compounds from representative databases (124) although by definition incomplete, as all the drug-like space is far from being determined, this and similar tools can... 

A Gantt chart or similar tool for managing tasks and milestones against a time line Measures and metrics to track progress Identification of quality assurance reviews... 

A cemented carbide is made by bonding tungsten carbide to another metal. The product is very strong and remains strong at high temperatures. Cemented carbides are used for rock and metal cutting. They can operate at 100 times the speed of similar tools made of steel. 

The chemicals stored in the inventory can be searched by exact structure, substructure, or similarity [26], Similarity searching aims at retrieving compounds that are similar to a query compound by one or more measures of similarity. A set of structural features of the target molecule is compared with those of each chemical in the database, generating a similarity measure by a chosen metric such as the Tanimoto coefficient [27]. More details about chemical similarity are given below in relation to the chemical similarity tool. 

The similarity tool should encode different similarity indexes, and since the similarity indexes make use of molecular descriptors, the tool should also be able to derive the numerical representation from the given structure or to upload it from an external file. As for all the tools included in the DSS, the use of the chemical similarity tool should lead to results (e.g., category... 

We focus on the combination of transcriptomics and metabolomics and more specifically on microarray data, which is currently the most used method for gene expression profiling and is used on a routine basis. In the first paragraphs, we briefly revise the extraction of mRNA or metabolites, their measurement, quality control of data, and analysis methods. Afterward two different types of data fusion and recent tools and publications are reviewed, followed by visualization methods for obtained data. Lastly, the metabolite annotation Web server MassTRIX is presented. This Web server allows combined analysis of transcriptomic and metabolomic data in the context of metabolic pathways. We compared the metabolomics part against similar tools and give a short outlook on the next version of MassTRIX, MassTRIX 4. 

These are just a few of the visual and interactive tools available for ontology matching. In the next section, we discuss similar tools that have been developed to support the related problem of schema matching. 

The nucleotide sequence databases can be screened by a number of sequence similarity tools and some protein identification applications, such as SEQUEST [58]. As it is difficult to predict coding sequences from raw genomic data, and in some cases the authors have not submitted the information to the database, the tools propose protein hits from translated raw DNA sequences. 

Jahnke et al. (1982) used the same (or, at least a quite similar) tool in 4450 m deep waters of the equatorial Pacific, at approximately 0° to 10° N, and approximately 140° W (MANOP-site). Here, the distances between the locations in which the harpoon sampler was used and in which, for reasons of comparison, pore water was obtained by compression after the sampling was carried out with the box corer, amounted to 300 m to up to 3000 m. In measurements, which were corroborated several times, Jahnke et al. (1982) found similar concentrations of nitrate, nitrite, silica, pH, and manganese. Yet, the concentrations of ZCO, alkalinity and phosphate were distinctly higher and displayed statistical significance. 

Human CYPs involved in metabolism can be easily characterized because of the tools that are commercially available. However, similar tools are not available for other drug-metabolizing enzymes like FMOs, UGTs, and sulfotransferases. There are no specific inhibitors or monoclonal anitibodies identified for any of the commercially available expressed UGTs or sulfotransferases. Due to the lack of necessary tools it is difficult to quantitatively assess their contribution to the overall clearance of drugs that are metabolized by these enzymes. 

In the manufacture of percussion caps and detonators the copper blanks are cut from copper strips and stamped to the required shape. The blanks are then plaeed in a gun-metal plate, with the concave side uppermost—a tool composed of a plate of gim-metal, in which are inserted a number of copper points, each of the same length, and so spaced apart as to exactly fit each point into a cap when inverted over a plate containing the blanks. The points are dipped into a vessel containing the cap composition, which has been previously moistened with methylated spirit. It is then removed and placed over the blanks, and a slight blow serves to deposit a small portion of the eap mixture into each cap. A similar tool is then dipped into shellac... 

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