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Structural druggability

Figure . A cross-section of the druggable proteome taken from Ref. 10. Proteins in dose proximity-in this dendrogram are members of the same gene famiiy and share sequence simiiarity and structure simiiarity in reguiatory and iigand-binding domains. 92 proteins that are part of the BioPrint in vitro pharmacoiogicai profiie are shown in pink and cover a representative portion of the druggabie proteome. Figure . A cross-section of the druggable proteome taken from Ref. 10. Proteins in dose proximity-in this dendrogram are members of the same gene famiiy and share sequence simiiarity and structure simiiarity in reguiatory and iigand-binding domains. 92 proteins that are part of the BioPrint in vitro pharmacoiogicai profiie are shown in pink and cover a representative portion of the druggabie proteome.
Key words Drug targets, Hot spots, Druggability, Flo-QXP, Pocket finder, Structure superimposition, Target promiscuity, Protein cavity... [Pg.141]

Fauman EB, Rai BK, Huang ES (2011) Structure-based druggability assessment-identifying suitable targets for small molecule therapeutics. Curr Opin Chem Biol 15 463 68... [Pg.161]

Kozakov D, Hall DR, Chuang GY et al (2011) Structural conservation of druggable hot spots in protein-protein interfaces. Proc Natl Acad Sci USA 108 13528-13533... [Pg.163]

Salzberg, A.C. and Huang, E.S. (2007) Structure-based maximal affinity model predicts small-molecule druggability. Nature Biotechnology, 25, 71-75. [Pg.109]

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See also in sourсe #XX -- [ Pg.207 ]



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