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Druggability predictions

Druggability prediction method Number of molecular targets... [Pg.819]

Fuller JC, Burgoyne NJ, Jackson RM (2009) Predicting druggable binding sites at the protein-protein interface. Drug Discov Today 14 155-161... [Pg.161]

Costa PR, Acencio ML, Lemke N (2010) A machine learning approach for genome-wide prediction of morbid and druggable human genes based on systems-level data. BMC Genomics 5(Suppl 11) S9... [Pg.162]

Salzberg, A.C. and Huang, E.S. (2007) Structure-based maximal affinity model predicts small-molecule druggability. Nature Biotechnology, 25, 71-75. [Pg.109]

Cheng, A. C., Coleman, R. G, Smyth, K. T., Cao, Q., Soulard, P., Caffrey, D. R., Salzberg, A. C., and Huang, E. S. (2007). Structure-based maximal affinity model predicts small-molecule druggability. Nature Biotechnology 25, 71-75. [Pg.32]

Reverse docking druggability qq novo design library prediction... [Pg.272]

Hurtt ME, Streck RD, Kumpf SW, et al. Fetal map A gene expression database for predicting potential involvement in developmental toxicity for all druggable genes. Birth Defects Res PtA. 2007 29 352. [Pg.178]

Al-Lazikani, B., Gaulton, A., PaoUni, G., Lanfear, J., Overington, J., Hopkins, A. The molecular basis of predicting druggability. In... [Pg.532]

A predicted pocket may often have borderline characteristics just below a safe druggability threshold. In this case, exploring the conformational plasticity of the pocket (see Subheading 2.1.4) may help to find conformations more relevant for small-molecule binding. [Pg.261]

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See also in sourсe #XX -- [ Pg.209 ]



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