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Drug Release from Electrospun Fibers

BiocompatibiUty is a desirable attribute in compositions designed for drug delivery (43). With surgical and subdermal implants, for [Pg.235]

The materials are obtained by electrospinning solutions containing tetracycline along with PLA, ethylene vinyl acetate (EVA) or a combination of PLA and EVA. The release of tetracycline hydrochloride was determined by spectroscopic measurements. [Pg.236]

Electroprocessed fibrin may be mixed with other fibrillar ma- [Pg.236]

Some preferred drugs or substances include, estrogen, androgen, cortisone, cyclosporin, peptide growth factors, nerve growth fac- [Pg.237]


The UV-cured film of IV-vinyl p30 rolidone has been used as a potential bioadhesive wound-dressing matrix when blended with other polymeric materials. Skin covers and wound dressings made of PVA and PVP were produced with or without polysaccharides by the help of the gamma irradiation technique. Because of its biocompatibility and nontoxicity, PVP was also chosen as the base material for a drug-loading device. Drug release from such membrane was found to depend on the crosslinking density, composition, and membrane thickness. On the other hand, PVP has been used as a carrier in electrospun fiber applications. [Pg.58]

Figure 8 In-vitro drug releases from core-shell electrospun sPLA/CA-cPEG/GS fiber mats at different CA content of 0%, 1% and 3% by weight. Figure 8 In-vitro drug releases from core-shell electrospun sPLA/CA-cPEG/GS fiber mats at different CA content of 0%, 1% and 3% by weight.
Figure 9 Model of drug releases from core-shell electrospun fibers (a) sPLA-cPEG/GS and... Figure 9 Model of drug releases from core-shell electrospun fibers (a) sPLA-cPEG/GS and...
Kenawy et al. studied the potential of electrospun fiber mats as drug delivery system for the release of tetracycline hydrochloride (Kenawy et al. 2002). Electrospun PEVA + PLA blended fibers were 1—3 pm in diameter while the PLA fibers were around 3-6 pm. Srinivasan and Reneker 1995 examined the crystal structure and morphology of the electrospun Kevlar fibers (Srinivasan and Reneker 1995). Fibers from 40 nm to a few hundreds of nanometers were produced. [Pg.217]

Rather than drag coating onto electrospun surface, Kenawy et al. [51] have examined the behavior of nanofibers composed of PLA and poly (ethylene-acetate co-vinyl) (PEVA) with incorporated drag. The fibers were prepared by dissolving the polymer with tetracycline hydrochloride drag, thereby producing polymeric fibers. This experimentation demonstrates a constant drug release over 5 days from the polymer nanofibers in electrospun PEVA and 50/50 PLA/PEVA mats. [Pg.297]


See other pages where Drug Release from Electrospun Fibers is mentioned: [Pg.89]    [Pg.235]    [Pg.196]    [Pg.89]    [Pg.89]    [Pg.235]    [Pg.196]    [Pg.89]    [Pg.441]    [Pg.487]    [Pg.225]    [Pg.226]    [Pg.227]    [Pg.228]    [Pg.248]    [Pg.249]    [Pg.192]    [Pg.474]    [Pg.493]    [Pg.778]    [Pg.1322]    [Pg.1326]    [Pg.192]    [Pg.193]    [Pg.275]    [Pg.278]    [Pg.279]    [Pg.287]    [Pg.150]    [Pg.234]    [Pg.236]    [Pg.287]    [Pg.289]    [Pg.290]    [Pg.291]    [Pg.481]    [Pg.482]    [Pg.252]    [Pg.224]    [Pg.382]    [Pg.234]    [Pg.263]    [Pg.268]    [Pg.377]    [Pg.381]    [Pg.179]    [Pg.697]    [Pg.57]    [Pg.118]   


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