Drug reaction with eosinophilia and systemic

Yang DC, Chang CM. Allopurinol-induced drug reaction with eosinophilia and systemic symptoms syndrome with recurrence. J Am Geriatr Soc 2010 58(10) 2043-4. 

Immunologic A hypersensitivity syndrome similar to Drug reaction with eosinophilia and systemic symptoms (DRESS) has been attributed to mexiletine [63" ]. 

Skin A 59-year-old woman of African origin took doxycycline as malarial prophylaxis for 3 weeks and developed a drug reaction with eosinophilia and systemic symptoms (DRESS), but patch tests with doxycycline were negative [60 ]. Her HLA phenotype was A3/A30 and B39/B42. 

Mardivirin L, Valeyrie-Allanore L, Branlant-Redon E, Beneton N, Jidar K, Barbaud A, Crickx B, Ranger-Rogez S, Descamps V. Amoxidllin-induced flare in patients with DRESS (drug reaction with eosinophilia and systemic symptoms) report of seven cases and demonstration of a direct effect of amoxicillin on human herpesvirus 6 replication in vitro. Eur J Dermatol 2010 20(1) 68-73. 

AGEP acute generalized exanthematous pustulosis, DRESS drug reaction with eosinophilia and systemic symptoms, EM erythema multiforme, FDE fixed drug eruption, niAbs monoclonal antibodies, NMBDs neuromuscular blocking drugs, NSAIDs nonsteroidal anti-inflammatory drugs, SJS Stevens-Johnson syndrome, TEN toxic epidermal necrolysis... 

D Orazio JL. Oxcarbazepine-induced Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS). Clin Toxicol (Phila) 2008 46(10) 1093. ... 

Kawakami T, Fujita A, Takeuchi S, Muto S, Soma Y. Drug-induced hypersensitivity syndrome drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome induced by aspirin treatment of Kawasaki disease. J Am Acad Dermatol 2009 60(1) 146-9. 

Skin The increased risk of a maculopapu-lar rash after the use of amoxicillin in patients with infectious mononucleosis has been illustrated by the case of a 24-year-old woman who developed such a rash after a single dose of amoxicillin 500 mg [89 ]. Reactivation of human herpesvirus 6 may also lead to skin reactions, as suggested by a series of seven cases of amoxicillin-induced flares in patients with drug reactions with eosinophilia and systemic symptoms (DRESS) due to other drugs in in vitro studies in a human T lymphoblas-toid MT4 cell line, amoxicillin increased replication of human herpesvirus 6 [90 ]. 

Wongkitisophon P, Chanprapaph K, Rattanakaemakom P, Vachiramon V. Six-year retrospective review of drug reaction with eosinophilia and systemic symptoms. Acta Derm Venereol March 2012 92(2) 200-5. 

Kang SY, Kim JY, Kim MY, Lee SY, Kim MH, Kim TW, et al. Drug-induced hypersensitivity syndrome/drug reaction with eosinophilia and systemic symptoms syndrome induced by cilostazol and carbamazepine. J Dermatol August 2012 39(8) 723-4. 

One case report of a drug reaction with eosinophilia and systemic symptoms (DRESS) was attributed to amikacin treatment of a septic arthritis. Patch testing and the presence of circulating amikacin sensitive T-cells confirmed the diagnosis [6 ]. Delayed-type hypersensitivity reactions are possible with all medicabons given and should be considered in a subject with prominent eosinophilia and systemic symptoms who are not responding as expected to treatment. 

Perry ME, Ahnaard N, Desai N, Larbalestier N, Fox J, Chilton D. Raltegravir-induced drug reaction with eosinophilia and systemic s)fmp-toms (DRESS) syndrome - implications for clinical practice and patient safety. Int J STD AIDS 2013 24(8) 639-42. 

Skin An 85-year-old male treated with acenocoumarol for stroke/systemic embolism prevention due to atrial fibrillation presented 6 weeks later with maculopapular exanthema of the trunk and limbs as well as purple lesions and blisters on the distal parts of his legs. Acenocoumarol was discontinued and enoxaparin, corticosteroids and antihistamines were administered one month later, the lesions had disappeared and laboratory parameters were normalized. This is a first report of drug reaction with eosinophilia and systemic symptoms for acenocoumarol [4 ]. 

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