Proteomics drug resistance prediction

Fig. 8. Drug-induced proteome changes predict for therapeutic resistance. (A) Mice bearing established >300 mm Fo5 (Flerceptin-resistant) and 1282 (Flerceptin-sensitive) tumors were treated with Flerceptin 30 mg/kg i.p. twice a week. Each data point represents mean tumor volume SD (Fo5, = 3 1282, n = 6). (B) Fo5 and 1282 tumors of equivalent size were harvested 24 and 48 h after a single dose of Herceptin i.p. and subjected to mass spectral proteomic profiling analysis. An example of a statistically significant change observed after Herceptin treatment in the 1282 tumors not observed in the Fo5 tumors is shown. The solid line trace (—) represents control, untreated tumors while the dotted line trace ( ) represents Herceptin-treated tumors. (Reprinted with permission from the American Association for Cancer Research from Cancer Research 64 9093-9100, 2004.)...

---