Drug-microcrystalline cellulose mixture

Millili GP, Schwartz JB. The strength of microcrystalline cellulose pellets the effect of granulating with water/ethanol mixtures. Drug Dev Ind Pharm 1990 16(8) 1411-1426. 

Celik, M., Ong, J. T., Chowhan, Z. T., and Samuel, G. J. (1996), Compaction simulator studies of a new drug substance Effect of particle size and shape, and its binary mixtures with microcrystalline cellulose, Pharm. Dev. Technol., 1,119-126. 

Resultant particles have a high glass transition temperature, which aids in stabilizing the amorphous state. These particles can be compressed into tablets. In one case, tablets containing 150 mg drug were pressed from a 1 1 mixture of the processed drug powder, microcrystalline cellulose and 5% carboxymethylcellulose. 

Inghelbrecht S. Remon, JP. Roller compaction and tableting of microcrystalline cellulose/ drug mixtures. Int J Pharm 1998 161 215-24. 

Tomer G, Podczeck F, Newton JM. The influence of type and quantity of model drug on the extrusion/spheronization of mixtures with microcrystalline cellulose. I. Extrusion parameters. Int J Pharm 2001 217 237 8. 

The effect of water with high mobility on drug degradation has also been demonstrated in the hydrolysis of a solid cephalothin mixture with microcrystalline cellulose.464 The hydrolysis rate was found to be proportional to the amount of water with high mobility rather than to the total amount of water, which included water with strongly reduced mobility. 

The tablet mass was fixed at 200 mg. Each unit contained 10 mg (5%) drug and 1.2% lubricant. It was considered that the lubricant level could be adjusted and optimized later as part of a process study. Thus, although there were 5 components in the mixture, 2 of them were fixed. The factor space in the remaining components, microcrystalline cellulose, lactose, and carbomer (totalling 93.8%) can be represented as a ternary diagram. The tablets were manufactured by direct compression of the powder mixture and the dissolution profiles were measured at pH 2 (0.01 M hydrochloric acid) and pH 7 (phosphate buffer). The time for 50% dissolution was measured in each case. 

Nevertheless, simpler suspending and flavouring agents can also be prepared at the dispensary (e.g. methylcellulose 1%, or other celluloses such as hypromellose, microcrystalline cellulose, sodium carboxy-methylcellulose at 1-2%, xanthan gels, pharmacopoeial syrups, or mixtures of the above). In some formulations suspending agents may not be required, for example, when it is known that the drug is soluble... 

Remon JP, Schwartz JB. Effect of raw materials and processing on the quality of granules prepared from microcrystalline cellulose-lactose mixtures. Drug Dev Ind Pharm 1987 13 1. 

---