Calcium channel blockers drug interactions

Batra S (1990) Interaction of antiestrogens with binding sites for muscarinic cholinergic drugs and calcium channel blockers in cell membranes. Cancer Chemother Pharmacol 26 310-312... 

Treatment recommendations cannot be derived firom such limited experience. Individual cases have been treated with calcium channel blockers and diuretics (26), nifedipine and diuretics (27), or sildenafil (27). Nifedipine decreased echo estimated RV systolic pressures from 90 to 84 mmHg (27). Median survival for all reported cases was 157 days (range 19-1036 days). Calcium channel blockers (28) and digoxin (29) avidly bind amyloid fibrils, producing locally toxic drug-myocardial interaction. Calcium channel blockers can worsen CHF in patients with amyloid cardiomyopathy and should be used cautiously (30). 

Ma, B., Prueksaritanont, T. and Lin, J.H. (2000) Drug interactions with calcium channel blockers possible involvement of metabolite-intermediate complexation with CYP3A. Drug Metabolism and Disposition, 28 (2), 125-130. 

Drugs that can significantly interact adversely with calcium-channel blockers include ... 

Drugs that may interact with nitrates include alcohol, alteplase, aspirin, beta-blockers, calcium channel blockers, dihydroergotamine, heparin, nondepolarizing muscle relaxants, phenothiazines, phosphodiesterase inhibitors (eg, sildenafil, tadalafil, vardenafil), and vasodilators. 

Drugs that may affect amiodarone include hydantoins, cholestyramine, fluoroquinolones, rifamycins, ritonavir, and cimetidine. Drugs that may be affected by amiodarone include anticoagulants, beta-blockers, calcium channel blockers, cyclosporine, dextromethorphan, digoxin, disopyramide, fentanyl, flecainide, hydantoins, lidocaine, methotrexate, procainamide, quinidine, and theophylline. Drug/Lab test interactions Amiodarone alters the results of thyroid function tests, causing an increase in serum T4 and serum reverse T3 levels and a decline in... 

The following drug classes may have a potential drug interaction with nevirapine Antiarrhythmics, anticonvulsants, antifungals, calcium channel blockers, cancer chemotherapy (cyclophosphamide), ergot alkaloids, immunosuppressants, motility agents, opiate agonists. 

Mibefradil, a calcium channel blocker, is not toxic when used alone for cardiovascular treatment but on the market it was found to interact with at least 25 other drugs, resulting in increased plasma concentrations and consequently, toxicity. This example was one that increased regulatory focus on drug-drug interactions but only common interactions can be researched premarketing and the commonality of multiple polytherapy, for example in the elderly, cannot be fully legislated. 

Drug interactions NSAIDs Salicylates Sulfonamides Chloramphenicol Probenecid Coumarins MAO inhibitors Beta-blockers Thiazides and other diuretics Corticosteroids Phenothiazines Thyroid products Estrogens Oral contraceptives Phenytoin Nicotinic acid Sympathomimetic Calcium channel blockers Isoniazid Miconazole... 

Lehmann, K.A., Kriegel, R., Ueki, M. Clinical relevance of drug interactions between opiates and calcium channel blockers, Anaesthesist 1989, 38, 110-115. 

In a meta-analysis of megatrials of simvastatin, the overall incidence of myopathy was 0.025% the same proportion of those with myositis had used calcium channel blockers as the proportion overall, suggesting that there is no important interaction between these two groups of drugs (32). 

Jones DR, Hall SD. Calcium channel blockers. In Levy RH, Thummel KE, Trager WF, et al., eds. Metabolic Drug Interactions. Philadelphia Lippincott Williams and Wilkins, 2000 333-345. 

F-D-C Reports, Inc. Roche Posicor withdrawn due to complexities of drug interactions, Roche says FDA cites 25 drugs dangerous in combination with the calcium channel blocker, June 9, 1998. 

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