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Drug-induced liver injury impairment

Monftoring drug therapy No biochemical markers fi om urine or blood have been established for detecting ciclosporin-induced renal injury. The serum concentration of indoxyl sulfate was high in patients with chronic renal impairment in 24 children with frequently relapsing steroid-dependent nephritic syndrome treated with ciclosporin, and renal biopsies showed chronic ciclosporin nephropathy in 13 of the 24 [19 ]. Of all studied biomarkers, only serum indoxyl sulfate was significantly raised in those with ciclosporin nephropathy. Indoxyl sulfate is synthesized in the liver from indole, a metabolite of protein-derived tryptophan produced... [Pg.611]

See other pages where Drug-induced liver injury impairment is mentioned: [Pg.346]    [Pg.445]    [Pg.465]    [Pg.300]    [Pg.312]    [Pg.98]    [Pg.626]    [Pg.649]    [Pg.762]    [Pg.413]    [Pg.195]   
See also in sourсe #XX -- [ Pg.340 , Pg.341 , Pg.342 ]



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Drug-induced

Drug-induced liver injury

Impaired

Impairment

Injury drug-induced

Liver drug-induced

Liver impairment

Liver inducible

Liver injury

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