Drug frameworks

Fig. 18.7 Molecular structures used in the SHAPES library. (A) Common drug frameworks used in the SHAPES library. The numbers denote the frequency of occurrence of each framework, and lone pairs indicate points of side-chain attachment...

There are relarively few important drugs which are alicyclic. Other than inhalation anesthetics, which are a special case, the compounds in the acyclic aliphatic class owe their activity to the functionality present and its specific spacing on the aliphatic framework. Thus, in most instances, the framework itself is not of comparable importance to the functionality attached to it. 

The nursing process is a framework for nursing action consisting of problem-solving steps that help members of the health care team provide effective patient care. It is both a specific and orderly plan used to identify patient problems, develop and implement a plan of action, and then evaluate the results of nursing activities, including the administration of drug . 

The core legislation governing the regulation of drugs in the EU is contained in two base Directives, which provide the framework for regulation of medicines at national level. These are ... 

One of the problems associated with reviewing the impact of ELNs within drug discovery is the issue of dehning exactly what we mean when we talk about such systems. There are many possible dehnition frameworks that allow for conceptual or functional descriptions of typical systems, and we explore some of these in more detail below. 

To analyze adverse drug events from an informatics framework, six major infrastructure elements must be in place ... 

In the near future new drugs for the treatment of Alzheimer s disease are expected to be licensed, and it would be extremely valuable to be able to compare them in a clear and well-defined framework. In addition, if economic evaluation is to inform health and social care providers and policy-makers about the potential impact of new interventions in practice, estimation of the value for money of these new interventions requires consideration of (a) the perceived and objective risks and benefits of care (b) attitudes of people with... 

While we should try to exploit such differences between NT systems in developing drugs, rather than adopting a blanket concept of neurotransmission, it is still worth while trying to characterise different types of NT systems in the CNS in order to build up a functional framework and concept. The following patterns are suggested (see Fig. 1.8). 

Figure 2.1 Study framework showing key components of drug regulation...

It should again be emphasized that at the onset of a new drug program, there are only small amounts of drug substance at hand. One of the first tasks for the preformulation scientist is to establish the framework within which the first clinical batches can be formulated. To this end it is important to know with which common excipients the drug is compatible. Below, the distinction will be made between solid and liquid dosage forms. 

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