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Drug discovery advances

Lipinski, C.A., Lombardo, F., Dominy, B.W. and Feeney, P.J. (1997) Experimental and computational approaches to estimate solubility and permeability in drug discovery. Advanced Drug Delivery Reviews, 23, 3-25. [Pg.268]

Chen, W.G., Zhang, C., Avery, M.J. and Fouda, H.G. (2001) Reactive metabolite screen for reducing candidate attrition in drug discovery. Advances in Experimental Medicine and Biology, 500, 521-524. [Pg.342]

Bennett PB, Guthrie HR. Trends in ion channel drug discovery Advances in screening technologies. Trends Biotechnol 2003 21 563-9. [Pg.577]

Lacetera, N., Cockburn, 1. M., and Henderson, R. (2004], "Do firms change capabilities by hiring new people A study of the adoption of science-based drug discovery," Advances in Strategic Management, 21,133-59. [Pg.190]

H. Van de Waterbeemd, Advanced Computer-Asissted Techigues in Drug Discovery John Wiley Sons, New York (1995). [Pg.299]

Also in the 1980s, structure-based drug design (SBDD) underwent a similar cycle. Early proponents oversold what could be achieved through SBDD, thereby causing pharmaceutical companies to reconsider their investments when they discovered that SBDD too was no panacea for filling the drug discovery cornucopia with choice molecules for development. Nevertheless, SBDD was an important advance. [Pg.25]

Roberts PM, Hayes WS. Advances in text analytics for drug discovery. Curr Opin Drug Discov Devel 2005 8 323-8. [Pg.119]

Downs GM, Willett P. Clustering of chemical structure databases for compound selection. In van de Waterbeemd H, editor, Advanced computer-assisted techniques in drug discovery. Weinheim VCH Verlag, 1994. p. 111-30. [Pg.374]

P.J. Lewi, Spectral mapping of drug-test specificities. In Advanced Computer-Assisted Techniques in Drug-Discovery (H. van de Waterbeemd, Ed.). VCH, Weinheim, Germany, 1994, pp. 219-253. [Pg.419]

Once potent ligands for a viral protein are identified, further advancement depends on demonstrating activity in cells. Unfortunately, reproducible in vitro viral replication assays for HCV have not been reported. There are scattered reports that a very low level of genome replication, or even virus production, can be observed under certain circumstances [56]. However, recently specific sequences yielding relatively reproducible replication, at consistently detectable levels have been reported [57]. In the coming years these may allow routine assays suitable for compound evaluation to be developed, but to date drug discovery must rely on other cell culture models. [Pg.74]

The last step of the drug discovery process involves the testing of lead compounds to address issues such as efficacy, bioavailability, and safety. Testing may include in vitro assays but ultimately would require a suitable disease model and studies in animals. Many compounds may need to be designed and synthesized to identify the one compound with all the desired properties. Such a compound can be advanced to preclinical studies and eventually to the clinic. [Pg.15]


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