Reactive metabolite screens

Chen, W.G. et al. 2001. Reactive metabolite screen for reducing candidate attrition in drug discovery. Adv. Exp. Med. Biol. 500 521. 

Reactive metabolite screen Reactive metabolites have been increasingly implicated in idiosyncratic toxicity... 

Applications of Quadrupole Time-of-Flight Mass Spectrometry in Reactive Metabolite Screening... 

Conventionally, metabolite identification and more specifically reactive metabolite screening typically uses an array of chromatographic and mass spectrometric methods, and may require multiple injections of the same sample. This is to ensure that enough information has been collected to detect all metabolites and to have sufficient fragmentation information available to elucidate structures. 

Cross-species comparison Reactive metabolite screens Reaction phenotyping Early PK screening Biliary excretion... 

Castro-Perez, J.M., Applications of quadrupole time-of-flight mass spectrometry in reactive metabolite screening, in Mass Spectrometry in Drug Metabolism and Pharmacokinetics, Ramanathan, R. (ed.), John Wiley Sons, Hoboken, NJ, 159, 2008. 

Cy Reactive Metabolite Screening and Covalent-Binding Assays... 

REACTIVE METABOLITE SCREENING AND CHARACTERIZATION 499 15.3.4 Identification of In Vivo Oxidative Metabolites... 

Chen WG, Zhang C, Avery MJ, Fouda HG. Reactive metabolite screen for reducing candidate attrition in drug discovery. In Biological Reactive Intermediates, Vol. 6, Dansette PM, Delaforge RSM, GUbon GG, Greim H, follow DJ, Monks TJ, Sipes IG. Eds. Kluwer Academic/Plenum, New York, 2001, pp.521—534. 

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