Drug development side effects

The quest for the perfect diet pill is far from over. Readers should use reputable Internet sites and other sources to keep abreast of new developments. In most cases, diet pills will only be recommended for obese individuals who fall into certain risk-based categories. All drugs have side effects the benefits must always outweigh the risks when you decide to take these pills. 

In a manner similar to that observed following treatment with antidepressant drugs, the side effects of dopamine receptor blockade occur rather quickly but the clinical benefits require 2 to 3 weeks, or more, to fully develop. This also implies that compensatory changes in brain function are required for these drugs to produce clinical benefits in psychotic patients. These changes most likely require the activation or inactivation of... 

I spoke of pharmaceutical companies earlier. It s no surprise that the pharmaceutical industry is hard at work developing drugs to improve NO status. One now being introduced is nebivolol, a drug in the beta-blocker family that is frequently prescribed by physicians to treat hypertension. Nebivolol is said to increase NO in the endothelium more than other beta-blockers do. But all of these drugs have side effects, as detailed in chapter 16. 

The total syntheses of penicillin and cephalosporin represent elegant tours de force that demonstrated once again the power of synthetic organic chemistry. These syntheses, however, had little effect on the course of drug development in the respective fields, since they failed to provide access to analogs that could not be prepared by modification of either the side chains or, as in the case of more recent work, modification of 6-APA and 7-ACA themselves. In order to have an impact on drug development, a total synthesis must provide means for preparing... 

Since many of the uses of antihistamines involve conditions such as rashes, which should be treatable by local application, there is some rationale for developing drugs for topical use. The known side effects of antihistamines could in principle be avoided if the drug were functionalized so as to avoid systemic absorption. The known poor absorption of quaternary salts make such derivatives attractive for nonabsorbable antihistamines for topical use. Thus, reaction of the well-known anti his-taminic drug promethazine (104) with methyl chloride leads... 

The sedation side effect commonly observed on administration of classical antihistaminic drugs has been attributed in part to the ease with which many of these compounds cross the blood brain barrier. There have been developed recently a series of agoits, for example, terfenadine (198), which cause reduced sedation by virtue of decreased penetration into the CNS. This is achieved by making them more hydrophilic. Synthesis of a related compound, ebastine (197),... 

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