Drug Design Evolution

In Vitro Ci ance Models In Vitro Absorption Models (CAC02) CombinatiOflal Chemistry Multi-parametric Cptimirattcn Lipinski Rule-of-5 hERG Screening rargef 

Human Recombinant Reagents Human Genome Sequence Wi de-Li gaud Profiling 

---

Guner, O.F. (2002) History and evolution of the pharmacophore concept in computer-aided drug design. Current Topics in Medicinal Chemistry, 2, 1321-1332. 

Mother Nature still continues to be a resource of novel chemotypes and pharmacophores, and an impressive number of modem drugs have been isolated from natural sources, many based on their uses in traditional medicine systems. " To a large extent, the use of natural products in drug design represents the natural evolution of this old tradition. It has been extensively documented that the traditional medicine systems of many cultures worldwide are based on plants,for example in countries like China and India where plants have formed the basis for traditional systems of medicines. According to Kim and Park, natural... 

Just as similar requirements under the FFDCA caused the evolution of the medicinal chemist and changes in the way in which chemists are trained and approach drug design, and similar requirements under the FIFRA effectively caused changes in the way in which organic chemists are trained and approach the design of... 

Evolution of Protein Wrapping and Implications for the Drug Designer... 

Why Should the Drug Designer Be Mindful of Molecular Evolution ... 

The spectacular development of the QSAR theories has dominated the recent evolution of drug-design, and the conditions for the use of these theories are now well established. Being constructed on a particular chemical formula, with an implicit common invariant chemical skeleton, these methods are not always able to go beyond the chemical frame of the particular family studied. 

Silverman, R. (1992). The organic chemistry of drug design and drug action. Academic Press. Smith, C. M. and Reynard, A. M. (1992). Textbook of pharmacology. W. B. Saunders. Sneader, W. (1985). Drug discovery the evolution of modem medicine. Wiley. 

In the year 1939, Schaumann first identified and recognized the presence of a quatemaiy-carbon-atom in the morphine molecule, whieh eventually formed an altogether new basis and opened up a new horizon in the field of drug design ofnareotie analgesics. Intensive research further led to the evolution of pethidine (meperidine) which incidentally combines both the properties of morphine and atropine. It possesses a quaternary carbon-atom and quite astonishingly a mueh simpler chemical structure to that of morphine. 

---