Diblock copolypeptides

Pochan D.J., Pakstis L., Ozbas B., Nowak A.P., and Deming T.J. SANS and cryo-TEM study of self-assembled diblock copolypeptide hydrogels with rich nano through microscale morphology. Macromolecules, 35, 5358, 2002. 

In 2000, the first example of ELP diblock copolymers for reversible stimulus-responsive self-assembly of nanoparticles was reported and their potential use in controlled delivery and release was suggested [87]. Later, these type of diblock copolypeptides were also covalently crossUnked through disulfide bond formation after self-assembly into micellar nanoparticles. In addition, the encapsulation of l-anilinonaphthalene-8-sulfonic acid, a hydrophobic fluorescent dye that fluoresces in hydrophobic enviromnent, was used to investigate the capacity of the micelle for hydrophobic drugs [88]. Fujita et al. replaced the hydrophilic ELP block by a polyaspartic acid chain (D ). They created a set of block copolymers with varying... 

Nowak AP, Breedveld V, Pakstis L et al (2002) Rapidly recovering hydrogel scaffolds from self-assembling diblock copolypeptide amphiphiles. Nature 417 424-428... 

Yang CY, Song BB, Ao Y et al (2009) Biocompatibility of amphiphilic diblock copolypeptide hydrogels in the central nervous system. Biomaterials 30 2881-2898... 

Kim W, Thevenot J, Ibarboure E et al (2010) 5elf-assembly of thermally responsive amphiphilic diblock copolypeptides into spherical micellar nanoparticles. Angew Chem Int Ed 49 4257 260... 

Investigations on diblock copolypeptide amphiphiles by Deming and coworkers further elegantly proved the dependence of the aggregation behavior on the chain conformation of the polymer blocks.225 Well-defined block copolymers were synthesized containing... 

To further test the conclusions based on the results described above, we synthesized a family of self-assembling diblock copolypeptides that incorporate the features found... 

Gibson MI, Cameron NR (2008) Organogelation of sheet-helix diblock copolypeptides. Angew Chem Int Ed 47 5160-5162... 

Pakstis LM, Ozbas B, Hales KD, Nowak AP, Deming TJ, Pochan D (2003) Effect of chemistry and morphology on the bioftinctionality of self-assembling diblock copolypeptide... 

Diblock copolypeptides containing two protein blocks have been prepared by the NGA technique. Gharacterization of their structure by rheology and X-ray scattering suggests that these materials also form microphase-separated structures. 

A.P. Nowak, V. Breedveld, L. Pakstis, B. Ozbas, D.J. Pine, D. Pochan, et ai. Rapidly recovering hydrogel scaffolds from seh-assembhng diblock copolypeptide amphiphiles. Nature, 417,424-8,2002. 

X. Zhang, J. Li, W. Li, and A. Zhang, Synthesis and characterization of thermo- and pH-responsive double-hydrophilic diblock copolypeptides. Biomacromolecules, 8 (11), 3557-67, 2007. 

Nowak, A.P. et al. Rapidlyrecovering hydrogel scaffolds from self-assembHng diblock copolypeptide amphiphiles. Nature, 2002,417 424-8. 

Various diblock copolypeptides were used to form sUica structures (Table 2). Cystein-lysine block copolypeptides were successfijl in fadhtating the sihca synthesis. 

In a related project, the Deming laboratory also investigated the use of diblock copolypeptides containing racemic hydrophobic segments as surfactants for... 

In 2004, Deming s laboratory studied the roles of chain length and block composition on the assembly of uncharged diblock copolypeptide amphiphiles of the general structure poly(77e-2-[2-(2-methoxyethoxy)ethoxy]acetyl-L-lysine)-Z loc -poly(L-leucine), or [88]. These diblock copolypeptide amphiphiles... 

Deming s group also reported in 2005 on the assembly of charged diblock copolypeptide amphiphiles, utilizing the structure-directing properties of rod-like... 

Fig. 5 Structure of amphiphilic glycosylated diblock copolypeptides and their assembly into vesicles. Adapted from [106]...

Since the polypeptide formed by the polymerization of an NCA with a simple amine is itself amine ended, sequential polymerizations can be conducted with different NCA monomers leading to AB diblock copolypeptides or, with a further cycle of operation using the original monomer, to ABA triblock copolymers. In the latter case, the outer A blocks may not be of equal lengths and, where such equality is required, a better procedure is to initiate the primary polymerization bidirectionally with a diamine according to the scheme of equation (24). " " ... 

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