Naltrexone drug delivery

Nalidixic acid, 3 29 21 104, 123, 215 year of disclosure or market introduction, 3 6t N-alkylation reactions of aniline, 2 785-786 microwaves in, 16 557-558 Naltrexone drug delivery, 9 65—66 Nameplate capacities, 23 547-548 Nametre viscometer, 21 739 NAND arrays, 22 258 Nanoaluminum composites, 10 19, 20 Nanoassemblies, shell and core cross-linked, 20 489-490 Nanocar, 24 62 Nanocarbon materials, 1 718-722 Nanoceramics, 1 705-708 Nanoclays, 11 313-314... 

C.G. Pitt, T.A. Marks, and A. Schindler, Biodegradable Drug Delivery Systems Based on Aliphatic Polyesters Application to Contraceptives and Narcotic Antagonists. Naltrexone Res. Monogr., 28,1980. 

Pitt, C. G. Marks, T. A. and Schindler, A. (1981) Biodegradable drug delivery systems based on aliphatic polyesters application to contraceptives and narcotic antagonists, in National Institute on Drug Abuse Research Monograph, (eds R. E. Willette and G. Barnett), Naltrexone, Volume 28, pp. 232-53. 

Six cases of complications loosely related to the use of naltrexone pellet implantation during the highly controversial rapid and ultra-rapid opioid detoxification procedures have been reported (22). These included pulmonary edema, prolonged opioid withdrawal states, drug toxicity, withdrawal from cross-dependence to alcohol and benzodiazepines, aspiration pneumonia, and death. The risk of these controversial procedures and of naltrexone in this novel delivery system are high a robust scientifically validated program of research is needed to justify such treatment packages. 

Figure 15.3 Blood plasma levels of Naltrexone after buccal and intravenous (i.v.) delivery of 10 mg of the drug.

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