Drug-carrier systems, properties

Initially, liposomes seemed to be optimal drug carrier systems, but further research in general showed disappointing results [97]. The clinical utility of what are now called conventional liposomes was limited by their rapid uptake by phagocytic cells of the immune system, predominantly in the liver and spleen, resulting in their largely uncontrollable properties upon administration in vivo. 

Uner M. (2006). Preparation, characterization and physico-chemical properties of solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) their benefits as colloidal drug carrier systems. Pharmazie, 61, 375-386. 

Gu, J.M., Robinson, J.R., Leung, S.S. (1988). Binding of acrylic polymers to mucin epithelial surfaces structure-property relationships. Critical Reviews in Therapeutic Drug Carrier Systems, 5, 21-67. 

Delgado, C., Francis, G.E. and Fisher, D., The uses and properties of PEG-linked proteins. Critical Reviews in Therapeutic Drug Carrier Systems, 9, 249, 1992. 

Dispersions of nanostructured lyotropic phases are very complex systems which, for example, often do not only contain a single type of particle. To be used as drug carrier systems compositions and preparation methods are required that reliably and repro-ducibly lead to the desired dispersion characteristics. Moreover, analytical methods capable to detect the relevant physicochemical properties have to be employed. 

Liposomes have been widely used as model membranes and their physicochemical properties have therefore been studied extensively. More recently, they have become important tools for the study of membrane-mediated processes (e.g., membrane fusion), catalysis of reactions occurring at interfaces, and energy conversion. Besides, liposomes are currently under investigation as carrier systems for drugs and as antigen-presenting systems to be used as vaccines. 

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