Drug action analysis

MFTA Models in Biotarget and Drug Action Analysis... 

Walters DE, Hopfinger AJ. Case studies of the application of molecnlar shape analysis to elucidate drug action. THEOCHEM 1986 27 317-23. 

Gunther EC, Stone DJ, Rothberg JM, Gerwien RW. A quantitative genomic expression analysis platform for multiplexed in vitro prediction of drug action. Pharmacogenomics J 2005 5 126-34. 

Staniforth DH, Rose D Statistical analysis of the lactulose/breath hydrogen test in the measurement of orocecal transit Its variability and predictive value in assessing drug action. Gut 1989 30 171-175. 

A number of commercial antibody-based microarrays for multiplexed cytokines analysis are now available (Beckman Coulter BD Biosciences Panom-ics Pierce S S Zyomyx and others). Cytokines are essentially biomarkers of cell injury, inflammation, and apoptosis. They are released by cells in culture in response to drug action (Turtinen et al., 2004) or are elevated in serum in various disease states. Moreover, numerous cytokines are involved in cellular response and many serve as dual effectors (Asao and Fu, 2000). As a result, anticytokine microarrays are being evaluated in drug discovery for off-target toxicity testing to replace standard ELISA plate formats. 

Currently, amantadine, vidarabine, trifluridine, idoxuridine, sciclovir, ribavirin, and zidovudine are used as antiviral drugs. An analysis of the mechanisms of action of existing and used viral drugs permits the conclusion to be made that they can increase resistance of... 

David, G. (2005) Covell Linking tumor cell cytotoxicity to mechanism of drug action An integrated analysis of gene expression, small-molecule screening and structural databases. Proteins Structure, Function, and Bioinformatics, 59 (3), 403-433. 

Spiegel, R., Dixon, K. Psychotropic drug experiments in normal subjects their relation to animal studies and clinical trials. In Spiegelstein, M.Y., Levy, A. (eds) Behavioral Models and the Analysis of Drug Action. Proc. 27th OHOLO Conf. Elsevier, Amsterdam, 1982, pp. 39-55. 

The first of these is the quantitative analysis of dose-dependent drug actions, for example, to infer dose-response relations from clinical correlates of variable compliance (Efron and Feldman, 1991 Urquhart, 1991a). 

Purpura, D. P. "Electrophysiological Analysis of Psychotogenic Drug Action. Archives of Neurology and Psychiatry 75, 122-31,... 

Hansch analysis attempts to mathematically relate drug activity to measurable chemical properties. It is based on Hansch s proposal that drug action could be divided into two stages ... 

The theoretical analysis of the metabolic fate of PAC or xenobiotics in general demands a systems approach since individual components of the metabolic networks are closely linked via common substrates or cofactors as well as allosteric enzyme regulation [40, 41]. As shown in a later section, drug catabolites especially affect cell physiology and thereby greatly impinge on cellular drug action. 

Core-Box Modeling in the Biosimulation of Drug Action 5.2.4.2 Model Quality Analysis... 

Before moving on to a drug-centred analysis of the effects of neuroleptics, I will conclude this chapter by evaluating the evidence for a disease-centred view of their action according to the headings outlined in Chapter 2. 

Ungerstedt U, Herrera-Marschitz M, Stahle L, Zetterstrom T (1982) Models for studying the synaptic mechanisms correlative measurements of transmitter release and drug altered behaviour. In Spiegelstein MY, Levy A (Eds), Behavioural Models and the Analysis of Drug Action, pp. 57-70. Elsevier, Amsterdam. 

Pharmacokinetics is defined as the quantitative analysis of the processes of drug absorption, distribution, and elimination that determine the time course of drug action. Pharmacodynamics deals with the mechanism... 

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