DPP

Pigment Red 254 [122390-98-1] 56110 diketopyrrolopyrrole (DPP) condensation of diisopropyl succiaate with -chloroben2onitrUe... 

Starting point for evaluating the settling characteristics of suspended solids for dilute systems. Note that from the definition of the Reynolds number, we can readily determine the settling velocity of the particles from the application of the above expressions (u, = /xRe/dpp). The following is an interpolation formula that can be applied over all three settling regimes ... 

Bu2CuLi, PhLi, or Ph2CuLi cleaved the Dpp group from an aziridine (63-83% yield), but Me2CuLi resulted in ring opening." ... 

The classical aza-Darzens reaction (between bromoenolates and imines) has been investigated by several groups in recent years, especially with respect to the design and execution of asymmetric variants. Both stoichiometric and catalytic methods have been studied thus, the reactions between N-Dpp imines and chiral ot-bromoenolates [49] (derived from Oppolzer s sultams Scheme 4.35) and between S-chiral sulfmylimines and achiral bromoenolates [50] (Scheme 4.36) have been reported. 

Gliptins (DPP-4 inhibitors) Sitagliptin Inhibit DPP-46 enhance prandial insulin secretion Oral... 

The incretin effect is reduced in type 2 diabetes, and this is attributed, at least in part, to reduced secretion of GLP-1. The biological actions of GLP-1 remain essentially intact in type 2 diabetes, but administration of extra GLP-1 is not a practical therapeutic option because the peptide is degraded rapidly if A < 2 min) by the enzyme dipeptidyl peptidase IV (DPP-4). DPP-4 cleaves the N-terminal dipeptide from many of the peptides that have either an alanine or a proline residue penultimate to the N-terminus (Fig. 6). 

In clinical studies, selective DPP-4 inhibition increased active circulating concentrations of GLP-1 and GEP by two- to threefold. This was associated with increased glucose-induced insulin secretion and suppression of glucagon secretion, although changes in satiety and gastric emptying have not been repotted. 

DPP-1V inhibitors Inhibition of the dipeptidyl peptidase IV (by sitagliptin or vildagliptin) prolongs the duration of action of endogenous GLP-1 and thereby... 

Dopa — see Phenylalanine, dihydroxy-Dopplerite structure, 6, 849 Douglasite structure, 6, 846 Down s syndrome Alzheimer s disease, 6,770 DPP A process, 6,911 Drugs absorption metals, 6, 774... 

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