Dosage studies

The small number of animals used in a pyramiding dosage study makes it difficult to do standard statistical comparisons. This difficulty can be overcome to a certain extent by taking advantage of two design aspects of the pyramiding protocol. First, pretreatment data can and should be obtained on all animals for all parameters examined or determined. In-study comparisons should be made both to pretreatment data and to concurrent control animals. Such comparisons can be made not only on... 

Study Drug N (n) Age (years) Diagnosis Study Design Medication Dosage Study Length Primary Results Side Effect or Safety Issues... 

At modest dosages in the 70-80 mg area orally, Indapex is both relaxing and sexually stimulating. The highest dosages studied seem to reveal a toxic component and few subjects chose to repeat these levels. 

The choice of an optimal and reasonably safe dose of a hormonal product varies with race and population, at least because of variations in body weight and possibly also differences in metabolic processes. Dosage studies, for example with very low-dose estrogen treatment, must therefore of necessity be conducted in different populations. In menopausal Chinese women, a daily dose of... 

Lacking the placebo control, the statistician is dependent on outside sources of information to assess the significance of the findings. When validation or qualification of findings is required, previous studies with similar patient populations, drug dosages, study design, and implementation are commonly used to check and interpret the results of studies that do not use a placebo. 

Carson, S. 1965 Chronic (l-year) oral dosage studies vlth Quartzan in dogs. Report froa Food and Drug Research Labs., Inc. to Hoffaann LaRoche, Ine. 

Carson, S. 1965 Chronic [I-year] Oral Dosage Studies with Qaarzan In Dogs. Report from Food and Drug Research Laboratories, Inc., to Hoffman-LaRoche, Inc. 

Figure I. Mediator dosage study results of kappa number measurements of IMS bio-pretreatments using ABTS, VA, and HBT as mediators. The confidence level associated with this pulping condition is 1.5 kappa number units.

The resulting total reflectance values are directly proportional to the chromophore content of each pulp. Each total reflectance value is the average of five measurements. Figure 3 summarizes the total visible reflectance results from the mediator dosage study. The confidence level associated with the total visible reflectance is 2.3 units for the pulping condition utilizing a high effective alkali (21.4%), low sulfidity (23.2%) and H-factor of 863. 

Starr and his associates [182] were among the earhest cHnicians to use D-T4 for the treatment of hypercholesterolemia. Oral doses of 2-4 mg/day depressed serum cholesterol levels in the majority of hyperlipemic patients. In most cases, the hypohpidemic response could be maintained for prolonged periods, up to 5 years, without increments in the dosage. Studies on a total of more than 4,000 patients showed a 20% decrease in serum cholesterol in 80-85% of those treated [183]. This was not the case with L-T4 on which patients tended to become refractory to its hypohpidemic effect [184,185]. 

Product or Placebo and Dosage Study Design Numbers of Subjects Included for Data Analysis Duration Gut Microbiota Profiles Anthropometric Measures and Metabolic Biomarkers Reference... 

Variations in dosages studied, as well as duration of action, often lead to inconsistent results. Isosorbide dinitrate is an active antianginal agent with a duration of action similar to nitroglycerin. Some reports of ineffectiveness may have been due to the ineffective dosage... 

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