Dorsolateral prefrontal cortex DLPFC

Reduced dysbindin-1 gene expression in dorsolateral prefrontal cortex (DLPFC) and hippocampal formation (HF) of schizophrenia cases studied with in situ hybridization. Asterisks in histograms indicate a significant difference between controls (darker bars) and schizophrenia cases (lighter bars). DLPFC reductions in dysbindin-1 (a) were found in all cell layers in the absence of any changes in the presynaptic marker synaptophysin (d) or the postsynaptic marker spinophilin A (g). The reductions found in the HF occurred in all areas except CA1. Graphs are accompanied by representative sections from normal (b, e, h, and k) and schizophrenia (c, f, i, and I) cases. Adapted from Weickert et al. (2004) for the DLPFC and Weickert et al. (2008) for the HF... 

Several studies have analyzed the cortical expression of the NR1 subunit in postmortem brain ( Table 4.2-2). These studies report conflicting results, including both an increased and a decreased NR1 transcript expression in temporal cortex, OCC, and Dorsolateral prefrontal cortex, DLPFC (Humphries et al., 1996 Sokolov, 1998 Le Corre et al., 2000 Dracheva et al, 2001). However, other studies have reported unaltered NR1 transcript levels in PFC and temporal cortices (Akbarian et al., 1996 Beneyto et al., 2007). In addition, the expression of total NR1 protein in both frontal and temporal cortices was not significantly... 

Xu et al. (2005) 8 NA 4.1 14.4 N-Back Task-related neural activity in the left DLPFC showed a significant interaction between test session working memory load. When smokers had smoked ad libitum, task-related activity in the left dorsolateral prefrontal cortex was relatively low for an easy task condition (1-back), and increased as task difficulty increased but when smokers were abstinent overnight, activity in the L-DLPFC was approximately as high at low task level as it was at more difficult levels. 

List of Abbreviations CKU, chronic ketamine users COMT, catechol-O-methyltransferase DA, dopamine DAT, DA transporters DLPFC, dorsolateral prefrontal cortex EC, entorhinal cortex MPFC, medial prefrontal cortex NET, norepinephrine transporters PFC, prefrontal cortex SN, substantia nigra VTA, ventral tegmental area TH, tyrosine hydroxylase WCST, Wisconsin Cart Sort Task WM, working memory... 

---