Docosahexanoic acid

A recently proposed explanation of PD involves the formation of adducts between dopamine and the products of the peroxidation of arachidonic acid and docosahexanoic acid (Liu et ah, 2008b). At least two compounds, hexanoyl-dopamine and propanoyl-dopamine, derived... 

Li, P., Kim, S. W., Datta, S., Pond, W. G., and Wu, G. (2008). Dietary supplementation with cholesterol and docosahexanoic acid affects concentrations of amino acids in tissues of young pigs. Nitric Oxide 19, 259-265. 

Sardine oil has similar fatty acids to other edible fats and oils and also contains longer-chain co-3 polyunsaturated fatty acids, such as eicosapentaenoic acid and docosahexanoic acid. Table 2 indicates that the principal polyunsaturated fatty acids of sardine oil are in the co-3 family. 

SDPS Phosphatidylserine containing docosahexanoic acid SDS Sodium dodecyl sulfate SM Sphingomyelin... 

Bhaskar, N., Hosakawa, M., and Miyashita, K. 2006b. Physiological effects of Eicosap-entanoic acid (EPA) and docosahexanoic acid (DHA) A review. Food Reviews Int., 22, 291-307. 

Sijtsma, L., and de Swaaf, M. E. 2004. Biotechnological production and applications of omega 3 polyunsaturated fatty acid docosahexanoic acid. Appl. Microbiol. Biotech-nol., 64,146-153. 

Pyridoxal phosphate has a clear role in lipid metabolism as the coenzyme for the decarboxylation of phosphatidylserine, leading to the formation of phosphatidylethanolamine, and then phosphatidylcholine (Section 14.2.1), and membrane lipids from vitamin Bg-deficient animals are low in phosphatidylcholine (She et al., 1995). It also has a role, less well defined, in the metabolism of polyunsaturated fatty acids vitamin Bg deficiency results in reduced activity of A desaturase and impairs the synthesis of eicosapentanoic and docosahexanoic acids (Tsuge et al., 2000). 

If the biosynthesis proceeds via a domino-cyclization, it would require a novel transformation, because the known reactions are not able to create such unfavored ring systems as that of 1. A possible substrate for a thermodynamically favorable reductive polycyclization with addition of 2 H atoms would be the allenic C2o-fatty acid 9,10,12,16,18,19-docosahexanoic acid (32). ... 

The following fatty acids are accepted linolic acid, linolenic acid, arachidonic acid, eicosapentenoic acid, docosahexanoic acid. 

Gaudette, D.C. and Holub, B.J. (1991) Docosahexanoic acid (DHA) and human platelet reactivity. J. Nutr. Biochem. 2 116-121. 

Gibson R. Long-chain polyunsaturated fatty acids and infant development. Lancet 1999 354 1919-1920. Hamano H, Nabekura J, Nishikawa M, OgawaT. Docosahexanoic acid reduces GABA response in substantia... 

I5-E2-IS0K is structurally identical to LGE2. Finally, it should be noted that peroxidation of docosahexanoic acid (DHA) generates similar y-ketoaldehydes designated as neuroketals (Bernoud-Hubac et al., 2001). 

Qiu X, Hong H, MacKenzie SL. (2001a) Identification of a delta 4 fatty acid desaturase from Thraustochytrium sp. involved in the biosynthesis of docosahexanoic acid by heterologous expression in Saccharomyces cerevisiae and Brassica juncea. J Biol Chem 276 31561-31566. 

Figure 2.1-13 Scheme of the continuous extraction of esters (eicosapentanoic acid (EPA)/docosahexanoic acid (DHA)) [51]. 

Li, X., S. Hong et al. 2011. Docosahexanoic acid-induced coronary arterial dilation Actions of 17S-hydroxy docosahexanoic acid on K-t- channel activity. 

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