Design diversity

Reynolds CH (1999) Designing diverse and focused combinatorial libraries of synthetic polymers. J Comb Chem 1 297-306... 

Key Words Biological activity cell-based partitioning chemical descriptors classification clustering distance-based design diversity selection high-throughput screening quantitative structure-activity relationship. 

There are three major sources for a typical corporate compound collection project-specific compounds accumulated over a long period of time through medicinal chemistry efforts for various therapeutic projects, individual compounds from commercial sources, and compounds from combinatorial chemistry. In practice, compound collections are often divided into subsets, for example, the diverse subsets for general HTS and target-focused subsets (such as kinase libraries or GPCR libraries). For library design, diversity and similarity are generally built into the libraries of compounds to be synthesized and/or purchased (73). 

Squire, J. M. (1986). Muscle Design, Diversity and Disease. Menlo Park, CA Benja-min-Cummings. 

Key Words Chemical diversity compound design diversity-oriented synthesis druglike compounds molecular properties natural products rule of five structure-activity relationship target-focused compound libraries. 

DESIGNING DIVERSE LIBRARIES BY ANALYSING PRODUCT SPACE... 

Brown RD, Hassan M, Waldman M. Tools for designing diverse, druglike, cost-effective combinatorial libraries. In Ghose AK, Viswanadhan VN, eds. Principles, Software Tools and Applications in Drug Discovery. New York Marcel Dekker, 2001 301-335. 

Fig. 5 Designed diversity in the silver organonitrile frameworks of Lee while still maintaining a honeycomb-type layered structure. Reprinted with permission from Ref [24]. Copyright 1999 by American Chemical Society.

Up to now, the matter was selection of suitable design diversity solution for some spectrum of demands, described with difficulty function 0(x). However, the... 

Littlewood, B., P. Popov, and L. Strigini (2001). Modelling software design diversity a review. ACM Computing Surv s 33(2), 177-208. 

Another option is design diversity each using different set of hardware and software. All these are detailed out in Chapter XI. 

Design diversity This approach is rather costly. It combines hardware and software fault tolerance in different sets of computing channels. Each channel is developed in different hardware and software in redundant mode to provide the same function. This method is deployed to identify deviation of a channel from the others. The goal is to tolerate both hardware and software design faults [7]. After developing a fault tolerant design it is necessary to validate it from a reliability point of view, discussed later. 

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