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Dissolution rate control

JB Dressman, D Fleisher. Mixing-tank model for predicting dissolution rate control of oral absorption. J Pharm Sci 75 109-116, 1986. [Pg.161]

Benita, S. and Donbrow, M. (1982) Dissolution rate control of the release kinetics of water-soluble compounds from ethylcellulose film-type microcapsules. International Journal of Pharmaceutics, 12, 251-264. [Pg.173]

Dissolution occurring by a surface reaction is often slower than by transport-controlled kinetics because the latter results from more rapid surface detachment. There appears to be a good correlation between the solubility of a mineral and the rate-controlling mechanism for dissolution. Table 7.1 lists dissolution rate-controlling mechanisms for a number of substances. The less soluble minerals all dissolve by surface reaction-controlled kinetics. Silver chloride is an exception, but its dissolution... [Pg.147]

TABLE 7.1 Dissolution Rate-Controlling Mechanism for Various Substances Arranged in Order of Solubilities in Pure Water (Mass of Mineral That Will Dissolve to Equilibrium)0... [Pg.148]

Quahty control during manufacture and of the final product assures batch-to-batch consistency and reflabiUty. Bioavadabihty is checked in early batches produced for clinical testing. Other tests include uniformity of weight and contents, hardness (qv), disintegration rate, dissolution rate, and friabihty. [Pg.229]

Under natural conditions the rates of dissolution of most minerals are too slow to depend on mass transfer of the reactants or products in the aqueous phase. This restricts the case to one either of weathering reactions where the rate-controlling mechanism is the mass transfer of reactants and products in the soHd phase, or of reactions controlled by a surface process and the related detachment process of reactants. [Pg.214]

Coated fertilizers achieve controlled release by coating a soluble fertilizer core (substrate) with a water-insoluble barrier which limits the access of water to the fertilizer and thus limits its dissolution rate. [Pg.130]

The low activation energies suggested that the dissolution rate is controlled by counterdiffusion of organic components from the coal surface and dissolved hydrogen from the solvent. Also, the rate of dissolution appeared to depend exponentially on hydrogen partial pressure. [Pg.2373]

XPS was used to determine the surface composition of the anodized aluminum substrate during exposure to warm, moist environments. The information obtained was used to construct surface behavior diagrams that showed that hydration of the surface involved three steps [38]. Step one, which was reversible, consisted of adsorption of water onto the AIPO4 monolayer. The second step, which was rate-controlling, involves dissolution of the phosphate followed by rapid hydration... [Pg.281]

In a detailed study the dissolution kinetics of shock-modified rutile in hydrofluoric acid were carefully studied by Casey and co-workers [88C01], Based on the defect studies of the previous sections in which quantitative measures of point and line defects were obtained, dissolution rates were measured on the as-shocked as well as on shocked and subsequently annealed powders. At each of the annealing temperatures of 200, 245, 330, 475, 675, 850, and 1000 °C, the defects were characterized. It was observed that the dissolution rates varied by only a factor of 2 in the most extreme case. Such a small effect was surprising given the very large dislocation densities in the samples. It was concluded that the dissolution rates were not controlled by the dislocations as had been previously proposed. [Pg.174]

Firstly, they might be expected to have an effect when corrosion occurs under conditions of active (film-free) anodic dissolution and is not limited by the diffusion of oxygen or some other species in the environment. However, if the rate of active dissolution is controlled by the rate of oxygen diffusion, or if, in general terms, the rate-controlling process does not take place at the metal surface, the effect of crystal defects might be expected to be minimal. [Pg.36]

Flow thins protective film to equilibrium thickness which is a function of both mass transfer rate and growth kinetics. Erosion corrosion rate is controlled by the dissolution rate of the protective film. [Pg.293]

Film-free conditions It has been observed for many metals that the magnitude of / i, (see Section 1.4) increases with temperature and that the activation energy for dissolution is low, suggestive of a diffusion-limited anode process when the migration of corrosion products away from the surface is rate controlling. Some examples of the value of the activation energy for this process are given in Table 2.4. [Pg.323]

Duncan and Frankenthal report on the effect of pH on the corrosion rate of gold in sulphate solutions in terms of the polarization curves. It was found that the rate of anodic dissolution is independent of pH in such solutions and that the rate controlling mechanism for anodic film formation and oxygen evolution are the same. For the open circuit behaviour of ferric oxide films on a gold substrate in sodium chloride solutions containing low iron concentration it is found that the film oxide is readily transformed to a lower oxidation state with a Fe /Fe ratio corresponding to that of magnetite . [Pg.943]

Fig. 8.2 Strain-generated active path mechanisms, (a) Often referred to as the film rupture model and (b) the slip step dissolution model. In both cases growth is by dissolution film rupture is the rate controlling step, not the mechanism of crack growth... Fig. 8.2 Strain-generated active path mechanisms, (a) Often referred to as the film rupture model and (b) the slip step dissolution model. In both cases growth is by dissolution film rupture is the rate controlling step, not the mechanism of crack growth...
Kassner used a rotating disc, for which the hydrodynamic conditions are well defined, to study the dissolution kinetics of Type 304 stainless steel in liquid Bi-Sn eutectic. He established a temperature and velocity dependence of the dissolution rate that was consistent with liquid diffusion control with a transition to reaction control at 860 C when the speed of the disc was increased. The rotating disc technique has also been used to investigate the corrosion stability of both alloy and stainless steels in molten iron sulphide and a copper/65% calcium melt at 1220 C . The dissolution rate of the steels tested was two orders of magnitude higher in the molten sulphide than in the metal melt. [Pg.1062]


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See also in sourсe #XX -- [ Pg.250 ]




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