Dissolution bioavailability

Zhang Y, WJ Maier, RM Miller (1997) Effect of rhamnolipids on the dissolution, bioavailability and biodegradation of phenanthrene. Environ Sci Technol 31 2211-2217. 

H. M. Abdou, Dissolution, Bioavailability, and Bioequivalence, Mack Pub., Easton, 1989. 

Tam KY. Potential of Using Cell Based Technology for Predicting Bioavailability. Amsterdam Dissolution, Bioavailability Bioequivalence, 2003. 

Abdou, H.M. Dissolution, Bioavailability and Bioequivalence Mack Pubhshing Company Easton, PA, 1989. 

An excipient is defined as a material that is deliberately incorporated into the formulation to aid some physicochemical process, for example for a tablet, integrity, dissolution, bioavailability or taste excipients are typically chosen from among many compounds without pharmacological properties (e.g. lactose), although there are examples where pharmacokinetics change with the excipient used. There are specialized examples of excipients, for example propellants are excipients that assist in the delivery of inhaled drugs to the respiratory tract. For intravenous infusions or ophthalmic products, the excipients are usually pH buffers or... 

Increase hydrophobicity of conjugate anion. DECREASE To control hygroscopicity inWettability INCREASE Dissolution/ bioavailability Increase polarity of conjugate anion. Lower pKa of conjugate acid. Attempt recrystallization from different solvents to alter crystal habit. Move to acid with high degree of hydroxylation. 

Abdou, H., ed. 1989. Theory of dissolution. In Dissolution, bioavailability bioequivalence, Easton, Penn., USA MACK Publishing Company, pp. 11-36. 

Abdou HM. Dissolution, Bioavailability and Bioequivalence. Easton, PA Mack Publishing Company, 1989. 

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