Solubility, Dissolution and Bioavailability Enhancement Case Studies

4 Solubility, Dissolution and Bioavailability Enhancement Case Studies 

In this chapter it was considered worthy of interest to quote those reports where solubility, dissolution, and/or pharmacokinetic studies have been performed on prepared ternary cyclodextrin complexes to correlate the dissolution with in-vivo exposure. 

The binary and ternary cyclodextrin complexes of vinpocetine (a poorly water-soluble base-type drug with significant peripheral vasodilator effect) with P-CD and HP-P-CD in the absence and prescence of HPMC (0.1% w/v) or PVP (0.25% w/v) have 

API Cyclodextrm used Polymer Method of preparation Dissolution media Remarks Ref. 

Arteether p-CD PVP Kneading, co-evaporation, freeze-drying Phosphate buffer (pH 6.8) PVP induced better solubihzing and complexing ability of P-CD as reflected by higher numericsd values of stability constant (Kc) and improved biological performance. [65] 

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See also in sourсe #XX -- [ , , , , , , , , , ]

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