Disintegrants generation, disintegrating force, pressure

Generation of a Disintegrating Force or Pressure as a Unifying Principle... 

From these simple data on a single-stroke research press, a formulator can begin to generate relationships between tablet properties and the compressional forces used to compact them. Thus, one could plot tablet hardness as a function of compaction force or pressure (see Fig. 2). The same would be true for disintegration tune, thickness, a dissolution number, etc. In fact, any dependent variable (tablet property) can be related to the independent variable (compaction force.) It is important to remember that force is the parameter one can control and, therefore, the independent variable. 

The apparatus used is known as a microfluidizer with a high-pressure positive displacement pump (500-200 PSI). A microfluidizer consists of small channels called microchannels through which product flows on to an impingement area, resulting in very fine particles of submicron range when pressure is applied by the attached pump Similar to the sonication method, this is also useful for small-batch production of nanoemulsions. Shear forces generated by ultrasonic cavitation result in production of vacuum bubbles which disintegrate the particles to nanometer scale... 

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