Disease lupus

The thiazide diuretics are used cautiously in patients with liver or kidney disease, lupus erythematosus (may exacerbate or activate the disease), or diabetes. Additive hypotensive effects occur when the thiazides are given with alcohol, other antihypertensive drugp, or nitrates. 

Antigen arrays, also described as reverse-phase protein arrays (Paweletz et al., 2001), involve the immobilization of proteins to serve as bait for various protein-protein interactions (Sreekumar and Chinnaiyan, 2002). For example, Joos et al. (2000) printed down various autoantigens present in sera with known associations with various autoimmune diseases such as Graves disease lupus connective tissue disease, and others. The group then screened various sera for the presence of autoantibodies. By immobilizing on the array a serial dilution series for each antigen, the titers for these antibodies could be determined. 

Contraindications Coronary artery disease, lupus erythematosus, rheumatic heart disease... 

Schallmoser, K., Rosin, C., Vormittag, R., et al. (2006), Specificities of platelet autoantibodies and platelet activation in lupus anticoagulant patients A relation to their history of thromboembolic disease, Lupus, 15(8), 507-514. 

Riboldi P, Gerosa M, Meroni PL. Statins and autoimmune diseases. Lupus 2005 14 765-768. 

Courts SM, Plunkett ML, Iverson GM, Barstad PA, Berner CM. Pharmacological intervention in antibody mediated disease. Lupus 1996 5(2) 158-9. 

Exposures to xenobiotics have been associated with the onset of several autoimmune diseases. Lupus (systemic lupus erythematosus or SLE), scleroderma (systemic sclerosis), rheumatoid arthritis, and other maladies... 

Nahonal Inshmte of Arthritis and Musculoskeletal and Skin Diseases. Lupus A Patient Care Guide for Nurses and Other Health Professionals, Chapter 1, Lupus Erythematosus, May 2001. Available at www.niams. nih.gov/hi/topicsAupusAupusguide/chpl.htm accessed January 2004. 

PT) 1, ll,V, VII, X Vitamin K deficiency Inherited factor deficiencies Warfarin Liver disease Lupus anticoagulant Afibrinogenemia trau ma, etc Easy bruising... 

Wide Range Autoimmune Diseases Lupus Syndrome Vasculitis with ANCA Hemolytic Anemia Autoimmune Hepatitis Dermatomyositis... 

Animal studies of alfalfa seed and seed sprouts have indicated some association between those products and the autoimmune disease lupus. The amount of alfalfa used in the studies, however, was highly excessive, with animals being fed diets containing 40% alfalfa sprouts or 45% alfalfa seed (Malinow et al. 1982 Montanaro and Bardana 1991). Related studies implicated the compound L-canavanine as being responsible for the effects of alfalfa. Although the compound is present in alfalfa seed and sprouts, it is not present in the mature herb that is the subject of this entry (Brown 2000 Farnsworth 1995 Malinow et al. 1982 Whittam et al. 1995). 

Figures IS.laand 18.1b are differential spectra of natural human blood serumand human blood serum concentrated five times. Figure 18.2 is a differential spectrum of normal human blood serum in which the reference cell also contained the same fluid. The figure shows a relatively flat baseline with which to compare abnormal specimens. Figure 18.3 shows marked diflerences in the spectrum of the blood serum from a patient with the disease lupus erythematosus disseminatus. Figure 18.4...

Several studies have reported that retinoids are effective for animal models of autoimmune diseases. Lupus nephritis is a major cause of mortality among systemic lupus erythematosus patients. ATRA inhibits IFN-y cytokine production from Thl and production and deposition to the kidneys of anti-DNA antibody IgG2a, and suppresses proteinuria and renal involvement in NZB/WFl mice, which are used as a lupus nephritis model (Nozaki et al. 2005). In an open clinical trial, seven patients with active lupus nephritis were treated with ATRA. As a result, four patients showed improvements in clinical symptoms and laboratory findings, including proteinuria and anti-dsDNA antibody levels. There were no adverse effects of ATRA therapy in any patient (Kinoshita et al. 2009). 

Furst DE. Pharmacokinetics of hydroxychloroquine and chloroquine during treatment of rheumatic diseases. Lupus 1996 5(suppl 1) S11-S15. 

Exposures to xenobiotics have been associated with the onset of several autoimmune diseases. Lupus [systemic lupus erythematosus (SLE)], scleroderma (systemic sclerosis), rheumatoid arthritis, and other maladies have been strongly associated with exposures to single chemicals and mixtures of chemicals. The single chemicals include sihca dust, VC, mercuric chloride, trichloroethylene, HCB, hydrazine, and tartrazine. Mixtures include epoxy resins, hair dyes, paint thinners and other (unspecified) organic solvent mixtures, industrial emissions, airborne particulate matter, and hazardous waste-site emissions [27-32],... 

Biological Applications Detecting cancer cells, spores, human papilloma virus (HPV), stress biomar-kers treating amyloid associated diseases, lupus, pathogen infections apoptosis assays cytotoxicity assays ... 

---