Discovery research suitable target compounds

The SAR of the bisacylhydrazines, both during and after the discovery of the commercial compounds, has been extensively studied. This was partly driven by the novelty of the chemistry, mode of action (ecdysone agonists via interaction with the ecdysone receptor), and the availability of suitable assays (tissue, cell and target site based). Numerous papers have been published on this subject and the reader is referred to an excellent review by Dinan and Hormann [6] as a starting point. This section highlights and summarizes the collective findings by various researchers. 

Abstract Nucleic acids were one of the first biological targets explored with DCC, and research into the application has continued to yield novel and useful structures for sequence- and structure-selective recognition of oligonucleotides. This chapter reviews major developments in DNA- and RNA-targeted DCC, including methods under development for the conversion of DCC-derived lead compounds into probe molecules suitable for studies in vitro and in vivo. Innovative applications of DCC for the discovery of new materials based on nucleic acids and new methods for the modification of nucleic acid structure and function are also discussed. 

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