Discoveries, table

Subsequently, the original Gif systems (described above, Gif1 and Gif11, respectively) [3] were subjected to various alterations named after the places of their discovery (Table 3.1). 

So what value do MCR methodologies bring to the discovery table The following come quickly to mind in chronological order from early to late stage discovery ... 

Table 2 lists the most-prescribed anti-inflammatory steroids on the U.S. market today. Table 2 shows that some of the first compounds to be marketed still have a place in the treatment of inflammatory disease 50 years and more after their discovery. Table 2 also illustrates that continued effort to improve potency, to increase safety and to find better drug delivery systems (e.g., inhalers) succeeded in creating marketable products into the 1990s. Today very little, if any, research is going on to find improved steroid anti-inflammatory drugs. Some work continues in the pharmaceutical development area mostly to improve the formulation of existing molecules and to find better delivery systems. 

The Value of Chemical Genetics in Drug Discovery Table 3.1 Natural products used to identify targets. 

In addition to systematic chemical nomenclature, the vitamins have an apparently illogical system of accepted trivial names arising from the history of their discovery (Table 1.1). For several vitamins, a number of chemically related compounds show the same biological activity, because they are either converted to the same final active metabolite or have sufficient structural similarity to have the same activity. 

Applications of MCR-Derived Heterocycles in Drug Discovery Table 6 Antibacterial activities of select pyrazolo-pyrido-pyrimidine-diones... 

Mixing. The ability to be mixed in existing equipment used in natnral Rubber Compounding (qv) was one factor that contributed to the easy acceptance of polychloroprene after its discovery (Table 9). Mixing of compounds of varions sizes can be performed on two-roll mills or in an internal Banbury mixer. A typical 20-min procedure follows ... 

A Medicinal Chemistry Perspective on the Hit-to-Lead Phase in the Current Era of Drug Discovery Table 12.2 Target class analysis of physical property expansion. 

Chapter 21 In Vitro ADME Profiling and Pharmacokinetic Screening in Drug Discovery Table 21.2. Pooling Strategies for Pharmacokinetic Evaluation of Drug Candidates... 

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