Medicinal chemistry perspective

The main issue with tight binding inhibition, from a medicinal chemistry perspective, is the limitations imposed by this behavior on following SAR. As the inhibitor affinity increases to the point where Arfpp is less than or equal to the enzyme con-... 

The review articles by Schramm (1998, 2003) provide a number of examples of the successful application of this protocol to the design of enzyme-specific transition state-like inhibitors. Among these, the transition state inhibitors of human purine nucleoside phosphorylase (PNP) are particularly interesting from a medicinal chemistry perspective, as examples of these compounds have entered human clinical trials for the treatment of T-cell cancers and autoimmune disorders. 

Kubinyi H. (2004) Drug discovery from side effects. In H Kubini, G Muller (eds), Chemogenomics in Drug Discovery — A Medicinal Chemistry Perspective, pp. 43-68. Wiley-VCH, Weinheim. 

Koch MA, Waldmann H. (2004) In H Kubinyi, G Mtlller (eds), Chemoge-nomics in Drug Discovery A Medicinal Chemistry Perspective, Wiley-VCH. 377-403. 

Lipids are naturally occurring organic molecules, isolated from animal or plant cells by extraction with nonpolar organic solvents. This definition defines lipids in terms of a physical property (solubility) and differs from structural definitions used for proteins or carbohydrates. Not surprisingly, lipids are highly varied in their structure from the medicinal chemistry perspective, there are five classes of lipids ... 

This subset was further investigated using the slower modeling methods to try to identify potential actives, known as plausible hits. An example of a molecule selected from the results of a docking experiment is shown in Fig. 4.8. This molecule had a similarity score of 0.93 to an active and is shown docked with the typical kinase inhibitor binding pattern. Both the active and the plausible hit are not drug-like from a medicinal chemistry perspective, but this example demonstrates well how the Feature Tree descriptor captures similarity between two molecules. 

Kubinyi, H. and Muller, G. (eds.). (2004) Chemogenomics in drug discovery, a medicinal chemistry perspective. In. Methods and Principles in Medicinal Chemistry , Wiley-VCH, Weinheim, Germany. 

From a chemist s perspective, it is necessary to interactively analyze and visualize screening results by structural scaffolds to identify chemical series that can be synthetically optimized. Depending on the business process, interactive HTS analysis from a medicinal chemistry perspective can be performed at any stage—after primary, concentration response, or secondary screening (Figure 14.1). 

A medicinal chemistry perspective on artemisinin and related endoperoxides 04JMC2945. 

In this chapter the biological function of PR, its structural properties and therapeutic indications for progestins will be described. Since steroidal progestins have now been in clinical use for several decades, the focus of this chapter will be more on the current developments, particularly in the area of nonsteroidal progestins mainly with a medicinal chemistry perspective. 

Role of the amino terminal domain in mGluRl. A medicinal chemistry perspective... 

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