Disc, BOhme

H. J. Bohm, Site directed structure generation by fragment joining, Perspect. Drug Disc. 

Bohm, H.-J. and Schneider, G. (Eds.). Virtual Screening for Bioactive Molecules. Wiley-VCH, Weinheim, 2000. Bajorath, J. Integration of virtual and high throughput screening. Nat. Rev. Drug Disc. 2002, 3, 882-894. 

Schneider, G. and Bohm, H.-J. Virtual screening and fast automated docking methods. Drug Disc. Today. 2002, 7, 64-70. 

Bleighee, K.H., Bohm, H.J., Muller, K., and Alanine, A.I. Hit and lead generation beyond high throughput screening. Nat. Rev. Drug Disc. 2003, 369-378. 

The action of the abrasive material on an area about 6 mm in diameter allows a hole of various depths to be made depending on the hardness of the material under test (Figs. 4.4.8 and 4.4.9). The readiness of measurement, the possibility of duplicating holes successively while conserving the measuring evidence, and the high reproducibility of results combined with the possibility of hardness dilferentiation in a wide range—all favour this device rather than Bohme s disc. 

Comparison of abrasiveness of selected samples of Lower-Silesian rocks determined with Bohme s disc and Mackensen blower, with causes of scatter of results indicated... 

Comparative studies of abrasiveness with Bohme s disc and the Macken-sen blower carried out by Balachanowski et al. (1973) on rock samples from Lower Silesia (Table 4.5.4, Fig. 4.5.15) revealed the existence of... 

The Bohme s disc method for petrochemical estimation of rocks now used appears to be equivalent to the dynamic abrasion method only for monolithic, monomineral rocks. For rocks softer than silica or those composed of minerals of distinct hardness, porous or partially weathered, no correlation is found between Bohme s method and Vickers hardness or any other hardness, and abrasive action on a surface 42-49 cm2 in area does not allow estimation of the structural and textural specificity of orientations in the rock under test. 

The abrasiveness test results by Mackensen s method for selected cubes of known abrasiveness on Bohme s disc, given in Table 4.5.4, show very clearly a way of detecting inhomogeneities in rock hardness, induced by structural and textural differences. By this method we can observe the influence of pockets, laminae or veins occurring in a rock, which have a different composition from the typical rock structure, and also the influence of cracks and weathering of rock on its overall hardness (abrasiveness). In the tests with cubes (previously used for Bohme tests), some 24 measurements were taken in each case (four on each face) by the Mackensen method. This is sufficient to give a comprehensive characterization of rock hardness, not possible in the same time with any other method (a single... 

Mackensen-Zeiss blower method, 39,101 Martens sclerometer, 48, 49 McGee s method, 92 Mean Mohs-Mackensen hardness, 106 Method, Blondel s 92 Bohme s disc, 90 Brinell, 36, 58 Davidenkov scratch point, 50 Davidenkov s, 50 dry friction without balls, 92 Harvey s 92... 

For grain size not bigger than 0.6 mm, the Bohme s disc ensures reproducibility of measurement in the limit of 1.5%, clearly distinguishing materials even of the same type but different origin. 

Minch s method is designed for determination of the abrasive power of powders and polishing micropowders, grain-size 160-3 (am. The test outfit miniaturized when compared to Bohme s disc, shows an average of three times lower wear of the glass plate for the same abrasive action time and the same grain size (A. Szymanski, 1972). 

Considered as a basic engineering parameter of rock materials, next to crushing and bending strength, is surface resistance to destructive mechanical action, defined as hardness or abrasiveness. Bohme s disc is generally recommended for rock materials, specifically for stone elements exposed to abrasive action and for rocks to be processed into concrete and terrazzo aggregate, whereas Deval s rattle method is recommended for railroad aggregate. 

In testing the abrasiveness of floor finish of man-made materials, special variations of Shore s scleroscope are commonest. For ceramic and rock floor tiles, the commonest testers are Bohme s disc and the Teledyne Abra-der. For sewage and chemical stoneware, the standards now in force recommend abrasiveness tests with the use of a sandblasting jet blower. For technical reasons, a more precise Mackensen blower method for stoneware testing has been in use in Poland for several years. From the experience gained over years, a standard recommending Mackensen s method has been laid down for stoneware abrasiveness tests. Research results proved the usefulness of this method also for other ceramic materials. 

Bfeicher KH, Bohm HJ, Miiller K, Alanine Al (2003) Hit and lead generation Beyond high throughput screening. Nature Rev Drug Disc 2 369-378... 

Bohm, H.-J., Flohr, A., Stahl, M. Scaffold hopping. Drug Disc. Today Technol. 2004, 7(3), 217-224. 

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