Diphosphoric esters

In 1912, Levene and Jacobs"" discovered that, on hydrolysis of thymus nucleic acid by means of boiling 2% sulfuric acid during two hours, diphosphoric esters of thymidine and of desoxyribosyr -cytosine may be isolated. ... 

The Adenosine Triphosphate System.— Fresh mammalian muscle contains about 0-01-0 02 per cent, of adenosine triphosphate, or adenyl pyrophosphate, a diphosphoric ester of adenylic acid which is a nucleotide assembled from adenine, D-ribose and phosphoric acid (p. 349). 

Tbiamine, aneurin or vitamin Bj is directly concerned with intermediate carbohydrate metabolism, and the extensive work of R. Peters has shown that in the form of its diphosphoric ester (co-carboxylase), it works in conjunction with the dicarboxylic acid system of Szent-Gy5rgyi in brii ing about the characteristic oxidation of pyruvate in brain tissue. 

Chemical Name 2-Methyl-l, 4-naphthalenediol diphosphoric acid ester tetrasodium salt Common Name —... 

If a sugar is esterified with two or more phosphate groups, the compound is termed bisphosphate, trisphosphate etc. (e.g. fructofuranose 1,6-bisphosphate). The term diphosphate denotes an ester with diphosphoric acid, e.g. adenosine S -diphosphate. 

DIPT, see Isopropyl ether Dipentyl, see Decane Diphenyl, see Biphenyl 1,1 -Diphenyl, see Biphenyl 4,4 -Diphenylenediamine, see Benzidine p,p -Diphenylenediamine, see Benzidine Diphenylenemethane, see Fluorene o-Diphenylenemethane, see Fluorene Diphenylene oxide, see Dibenzofuran Diphenyl ether, see Phenyl ether s/m-Diphenylhydrazine, see 1,2-Diphenylhydrazine lV,A/ -Diphenylhydrazine, see 1,2-Diphenylhydrazine Diphenylnitrosamine, see IV-Nitrosodiphenylamine Diphenyl-lV-nitrosamine, see IV-Nitrosodiphenylamine A,lV-Diphenylnitrosamine, see IV-Nitrosodiphenylamine A,Al-Diphenyl-lV-nitrosamine, see IV-Nitrosodiphenylamine Diphenyl oxide, see Phenyl ether Diphenyltrichloroethane, see p,p -DDT Diphosphoric acid, tetraethyl ester, see Tetraethyl pyrophosphate... 

TRISAMMONIUM GERANYL DIPHOSPHATE (Diphosphoric acid, mono(3,7-dimethyl-2,6-octadienyl) ester (E)-, trisammonium salt)... 

Its properties resemble those of the preceding substance. One molecule of nitric acid is readily lost by the compound, which is then transformed into triethanolamine trinitrate. The latter is also unstable and inclined to undergo decomposition. Diphosphoric salt of the trinitric ester was claimed to be an effective remedy against angina pectoris, instead of nitroglycerine. 

Diphosphoric acid appears to be a specific catalyst for the formation of coumarins from 1,3-dimethoxybenzene and /3-keto esters (62JOC4704). An interesting aspect of this synthesis is the cleavage of the ether function involved in the cyclization. 

Monosaccharides are activated for participation in glycosylation reactions by conversion into diphosphoric or phosphoric ester derivatives. 

DIPHOSPHORIC ACID, DISODIUM SALT see DXF800 DIPHOSPHORIC ACID TETRAETHYL ESTER see TCF250... 

The mono- and diphosphoric acid esters of the sugars are particularly important in enzymatic carbohydrate metabolism. The phosphate group is attached to the glycosidic... 

Diphosphoric Acid Tetraethyl Ester A200 Industrial 152... 

X-Ray structures have been completed for the caged carbophosphorane (95) and the cyclohexylammonium salt of the di-/3-naphthyl ester of diphosphoric acid. The latter is a model compound for conformational studies on physiologically active diphosphates where hydrogen-bonding is probably important. The... 

The preparation of macrocyclic ligands by a direct alkylation of metal-coordinated amines using a template effect is rare because the complexed amine is seldom a good nucleophile. The complexed anilines, on the other hand, can be deprotonated, which enhances the nucleophilicity of the nitrogen atom. Such a reaction of a complexed diphosphorous-containing bisaniline with a ditosylate ester gave the complexed macrocyclic ligand (method AC-1) (Ansell et al., 1985). 

DIPHOSPHORIC ACID, TETRAETHYL ESTER (107-49-3) CgHjcO Pj Reacts with water, forming phosphoric acid and flammable ethylene gas. Alkalis or elevated temperatures above 300°F/149°C can cause deconqjosition, forming flammable ethylene gas and toxic phosphoms oxides. Reaction... 

DIPHOSPHORIC ACID, TETRAETHYL ESTER (107-49-3) Reacts with water, forming phosphoric acid and flammable ethylene gas. Alkalis or elevated temperatures above 300°F/150°C can cause decomposition, forming flammable ethylene gas and phosphorus oxides. Aqueous solution is incompatible with sulfuric acid, alkalis, ammonia, aliphatic amines, alkanolamines, alkylene oxides, amides, epichlorohydrin, nitromethane, organic anhydrides, isocyanates, vinyl acetate. Attacks some plastics, rubber, and coatings. Corrosive to metals in the presence of moisture. 

There has long been the belief that DES may have a direct local action on the prostatic cancer, and it has been claimed [40] that orchidectomy and DES was clinically more effective than either form of therapy alone. The rationale behind the use of fosfestrol (DES 4,4 -diphosphoric acid ester, Honvan, (2)) in large doses (200 mg daily) is that the free and locally active form of the drug DES would be released within the tissue by the high concentrations of phosphatases present in prostatic cells. There is little evidence that fosfestrol accumulates in the prostate or that DES is released in reasonable concentrations [41]. Such evidence, however, still does not preclude the possibility that DES has a cytotoxic action in the prostatic cell and studies continue to attempt to identify this effect. 

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