Diphenylacetic acid 2- ethyl

Doxapram Doxapram, l-ethyl-4-(2-morpholinoethyl)-3,3-diphenyl-2-pyrrolidinone (8.2.4), is synthesized in the following manner. Diphenylacetonitrile in the presence of sodium amide is alkylated with l-ethyl-3-chlorpyrrolidine, giving (l-ethyl-3-pyrrolidinyl) diphenylacetonitrile (8.2.1). Acidic hydrolysis of the nitrile group gives (l-ethyl-3 pyrrolidinyl)diphenylacetic acid (8.2.2). Reacting this with phosphorous tribromide... 

Diphenylacetic acid has been obtained by the reduction of benzilic acid with hydriodic acid and red phosphorus 1 by the treatment of phenylbromoacetic acid with benzene and zinc dust,2 or with benzene and aluminum chloride 3 by the hydrolysis of diphenylacetonitrile 4 by heating a-diphenyldichloroethyl-ene with alcoholic sodium ethylate 5 by heating benzilic acid 6 from diphenylmethane, mercury diethyl, sodium and carbon dioxide 7 by the oxidation of a,a,5,S-tetraphenyl- 8-butine 8 by the decomposition of some complex derivatives obtained from diphenylketene 9 by the hydrolysis of diphenyl-5,5-hydan-toin 10 by the treatment of diphenylbromoacetic acid with copper 11 by the oxidation of dichlorodiphenylcrotonic acid.12... 

Diphenylacetic acid 2-(diethylamino)ethyl ester Platinum... 

In 1949 Arnold and Searles [13] reported that allyl, crotyl and 1-methylallyl diphenylacetates, when treated with mesitylmagnesium bromide or sodium hydride, rearrange to the respective a-substituted diphenylacetic acids. Rearrangement of allyl a-ethyl phenyl acetate could also be effected with stronger base like MgBrNEtj, albeit in very low yields (Scheme 5.1.2). The method was further extended to the synthesis of 9-fluorenecarboxylic acid [14] (Scheme 5.1.3). 

A suspension of a-(l-ethyl-3-pyrrolidinyl)-a,a-diphenylacetic acid in dry chloroform treated with dry HGl-gas until soln. is complete, SOGlg added to the soln. of the resulting hydrochloride, and refluxed 2 hrs. 4-(2-chlorethyl)-3,3-diphenyl-l-ethyl-2-pyrrolidinone. Y 75%. F. e. s. G. D. Lunsford et ah, J. Med. Ghem. 7, 302 (1964). 

Ethoxy-1,2-dinitrobenzene, in D-00961 2-Ethoxy-2,2-diphenylacetic acid, in H-00166 2-[[2-(2-Ethoxyethoxy)ethyl](2-ethoxyethyl)... 

Chemical Name a-phenylbenzeneacetic acid 1-ethyl-3-piperidinyl ester Common Name N-ethyl-3-piperidyl diphenylacetate Structural Formula ... 

Acyl radicals and acyl anions are proposed intermediates in the reduction of phenylacetyl chloride and hydrocinnamoyl chloride at mercury in MeCN [223]. Among the products obtained from the reduction of phenylacetyl chloride are 1,4-diphenyl-2-butene-2,3-diol diphenylacetate, phenylacetaldehyde, toluene, 1,3-diphenyl-acetone, and l,4-diphenyl-2,3-butanediol, as well as phenylacetic acid and phenylacetic acid anhydride. Analogous products arise from the reduction of hydrocinnamoyl chloride l,6-diphenyl-3-hexene-3,4-diol dihydrocinnamate, hydrocinnamaldehyde, ethyl benzene, l,6-diphenyl-3,4-hexanediol, hydrocinnamic acid, and hydrocinnamic acid anhydride. 

Adiphenine Hydrochloride, a-Phenylbenzeneace-tic acid 2 (diethyhmino)ethyl enter hydrochloride 2-diethyl-aminoethyl diphenylacetate hydrochloride diphenylacetyldi -ethylaminoethanol hydrochloride Trasentine hydrochloride Dipfiacif hydrochloride Spasmolytin Difacil hydrochloride Patrovina. C H CINO. mol wt 347,87. C 69.05% H 7.53%, Cl IQ.]9%, N 4.03%, O 9.20%. Antiniuscarinic anti-spasmodic. Prepd by the action of diphenylacetyl chloride or diphenyl ketene on diethylaminoethanol Swiss pat, 190,541 0937 to Ciba) Ger. par . 626,539 653,778 (1937), Crystal and molecular structure Guy, Hamor, J. Chant,... 

Piperidolate. a-Phenylbenzeneaeetie acid I-ethyl-3-piperidinyt ester diphertylacetic acid l-ethyl-3-piperidyl ester N-ethyl -3 -piperidyl diphenylacetate JB 305. 

CAS 76-89-1 EINECS/ELINCS 200-991-1 Synonyms Benzeneacetic acid, a-hydroxy-a-phenyl-, methyl ester Benzilic acid methyl ester Ethyl hydroxydiphenylacetate Ethyl 2-hydroxy-2,2-diphenylacetate Ethyl a-hydroxydiphenylacetate Ethyl a-phenylmandelate Hydroxydiphenylacetic acid, methyl ester Methyl benzillate Methyl diphenylglycolate Methyl hydroxy (diphenyl) acetate Methyl-2-hydroxy-2,2-diphenyl acetate Empirical C15HI4O3... 

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