4.5- diphenyl-2-trifluoromethyl

Diphenyl(trifluoromethyl)phosphane was obtained in a yield of ca. 20% from triphcnylphos-phane and trifluoroiodomethane.30... 

Herbicides can be grouped according to common stmctural features. Sometimes the assignment is arbitrary when there are a multitude of functional groups, eg, acifluorfen which is a diphenyl ether (phenoxy compound) as well as a trifluoromethyl compound. 

Pteridine, 6,7-dimethyl-4-trifluoromethyl-structure, 3, 266 Pteridine, 6,7-dioxotetrahydro-electrochemistry, 3, 285 Pteridine, 6,7-diphenyl-Isay s synthesis, 3, 309 Pteridine, 6,7-diphenyl-7,8-dihydro-synthesis, 3, 312... 

This dialkoxydiphenylsulfurane has been prepared by the reaction of diphenyl sulfide, 2,2,2-trifluoro-l-phenyl-l-(trifluoromethyl)ethyl hypochlorite, and potassium l,l,l,3,3,3-hexafluoro-2-phenyl-2-propanolate and by the reaction of diphenyl sulfide with 1 equivalent of chlorine and 2 equivalents of potassium 1,1,1,3,3,3-hexafluoro-2-phenyl-2-propanolate in diethyl ether. ... 

Synthetic applications of organosulfur reagents are expanding rapidly. Stable sulfuranes are included for the first time in BIS[2,-2,2-TRIPLUORO-l-PHENYL-l-(TRIFLUOROMETHYL)ETHOXY] diphenyl SULFURANE and DIETHYLAMINOSULFUR TRI-FLUORIDE. The latter is used to transform an alcohol to a fluoride in p-NITROBENZYL FLUORIDE. The direct homologation of a ketone to a nitrile by use of p-TOLYLSULFONYLMETHYL ISOCYANIDE is illustrated in 2-ADAMANTANECARBONITRILE. Reagents with... 

It should be pointed out that there are some methylene cyclopropene derivatives, whose stability is ascribed mainly to inductive effects brought about by strongly electron-withdrawing substituents. Thus, l,2-bis(p-tolyl)-4,4-(bis-trifluoromethyl)-triafulvene (63) synthesized recently by Agranat66 is a perfectly stable molecule with a dipole moment (7.42 D) comparable to that of l,2-diphenyl-4,4-dicyano-triafulvene (64) of the resonance-stabilized type (l)67 (7.9 D). 

The molecular structures of diphenyl cyclopropenone (anhydrous148 and as hy-drate13s 149 diphenylcyclopropene thione1501, 1,2-diphenyl-13S and 1,2-dimethyl-lsu 4,4-dicyano triafulvene, l,2-di-(p-tolyl)-4,4-di-(trifluoromethyl) triafulvenelslb), 5,6-diphenyl-1 S2 and 5,6-di-n-propyl-153 1,2,3,4-tetrachlorocalicene and 8-cyano-8-(diphenylcyclopropenyl)-heptafulvenylium tetrafluoroborate111 have been determined by X-ray analysis15 4). 

In 41c, the high dipole moment, 7.42 D compared with 2.79 D for 1,1-diphenyl-2,2-bis(trifluoromethyl)ethylene, indicates a strong ground state polarization, but no barrier data are available (98,119). 

BIS[2,2,2-TRIFLUORO-l-PHENYL-l-(TRIFLUOROMETHYL) ETHOXY] DIPHENYL SULFURANE... 

SYNTHESIS OF (45, 55)-[(f -l,5-CYCLOOCTADIENE)- 2-(2-PHEN YL-5-METHYL, 5-DIHYDRO-OXAZOL-4-YL)-1,3-DIPHENYL-2-DIPHENYLPHOSPHINITE-PROPANE IRIDIUM(I)]-TETRAKIS[3,5-BIS(TRIFLUOROMETHYL)PHENYL]BORATE... 

BIS(SALICYCL1DENE)ETHYLENE-DIIM1NO COBALT(Il), 57, 78 BlS[2,2,2-TRIFLUORO-l-PHENYL-l-(TRIFLUOROMETHYL)ETIIOXY ] -DIPHENYL SULFURANE, 57, 22 l,2-BlS(TRIMETHYLSlLYLOXY)CYCLO BUTENE, 57, 1... 

Studies on acetylenic molecules have been less extensive than those on alkenes diphenylacety-lene is converted at — 78 °C in Freon in the presence of calcium oxide with 2.5 equivalents of trifluoromethyl hypofluorite into l,l,2-trifluoro-l,2-diphenyl-2-(trifluoromethoxy)ethane (31) in 75% yield.37... 

There have been some further examples of the use of the Conrad-Limpach reaction on substituted 5-aminoquinolines for the synthesis of 4-hydroxy-1,7-phenanthrolines, although the products (see Section IV,F,1) should properly be designated as phenanthrolinones.169 Hot diphenyl ether is often employed as the medium for ring closure.170 Ethyl trifluoro-acetoacetate has been used successfully in place of ethyl aceto-acetate, and this variation has allowed entry to 2-trifluoromethyl-substituted 1,7-phenanthrolines.96 Extensions of the Conrad-Limpach type of synthesis starting with m-phenylenediamine (20) and utilizing diethyl ethoxymethylene malonate or ethyl ethoxalylacetate, reagents frequently used in quinoline syntheses, have afforded, after hydrolysis,... 

Disulfides are generally oxidized with cleavage of the S —S bond. Hypofluorous acid in acetonitrile solution oxidizes sulfur atoms in bis(trifluoromethyl) disulfide to the highest oxidation state and, in addition, inserts an oxygen bridge between the sulfur atoms (Table 19).304 A sulfonyl chloride 18 is similarly obtained by the reaction of a substituted diphenyl disulfide with hypochlorous acid generated from chlorine and aqueous acetic acid.305... 

Bis-[trifluoromethyl]-6-(diphenyl-methylen)-4-phenyl-5-(2,4,6-trimethyl-phenyl)- El4a, 356 [Ar2C = CO +... 

The first step in the overall synthetic scheme (Scheme 6) is the condensation of an appropriate carboxylic acid with trifluoroacetaldehyde. The carboxylic acid is chosen to impart specificity for the target enzyme. In one example,[28 the dianion of cyclohexanepropanoic acid (29) was formed by the addition of LDA and then quickly condensed with trifluoroacetaldehyde to form the p-hydroxy acid 30 as a racemic mixture of erythro- and threo-isomers. The p-hydroxy acid 30 is then protected with TBDMSOTf forming 31. Diphenyl phosphorazidate, TEA, and benzyl alcohol were then utilized in a Curtius rearrangement of the protected alcohol 31, which proceeds through an isocyanate intermediate that yields the protected amino alcohol 32 upon reaction with benzyl alcohol. In order for this step to occur at an appreciable rate, a second equivalent of triethylamine had to be added. The amino alcohol 32 was then deprotected and coupled with Boc-Phe-Leu-OH to give the trifluoromethyl alcohol 33, which was oxidized to the corresponding trifluoromethyl ketone 34 as a 1 1.2 mixture of diastereomers using the Dess-Martin periodinane procedure. Thus far, the compound shown in Scheme 6 is the only compound that has been synthesized by this method, but it is reasonable to assume that many other similar fluoro ketones can be produced by this scheme. 

We also note the chemical shifts at C-2 and C-4 for two 2-aryl-4,4-bis(trifluoromethyl)-4//-thiazines (24) (83CC945) along with the chemical shifts of four carbons for twelve 4//-thiazine-4-ones (102) (86PS327). The chemical shifts of four carbons from two 4,6-diphenyl-2//-thiazine-2-thiones (103) [82JCS(P1)2149] and the chemical shifts of the carbons from 2-substituted-4-methyl-6//-thiazine-6-thiones (104) are also shown (81BSB75). (See structures 24,102-104.)... 

Similarly, kinetic experiments have shown that superelectrophilic carboxonium dications are involved in the cyclodehydrations of 1,3-diphenyl-l-propanones.4a Several examples of the cyclodehydrations were described, including the trifluoromethyl-substituted system (Scheme 14 ... 

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