3,7-Dioxo-6-methyl-3,7-dihydro

HO h3c,J no2 L5s -xooh H11C6-N=C = N-C6H / (HsC2)20 h JU 0 3,7-Dioxo-6-methyl- 3,7-dihydro-2,I- benzoxazol-I-oxid E14b, 876 (1990)... 

Purine, 1,6-dihydro-8,9-dimethyl-6-thioxo-synthesis, 5, 583 Purine, 2,6-dimethoxy-synthesis, 5, 596 Purine, 2,6-dimethoxy-7-methyl-rearrangement, 5, 558 Purine, 2,7-dimethyl-halogenation, 5, 547 Purine, 7,9-dimethyl-UV spectra, 5, 517 Purine, 8,8-dimethyl-synthesis, 5, 580 Purine, 6-dimethylamino-mass spectra, 5, 519 occurrence, 5, 600 Purine, 6-dimethylamino-9-benzyl-alkylation, 5, 531 Purine, 3,7-dimethyl-6,8-dioxo-methylation, 5, 534 Purine, 6,8-dioxo-alkylation, 5, 534... 

Thermolysis of methyl l-methyleneamino-4,5-dioxo, 5-dihydro-lW-pyrrole-2-carboxylates 123 led to substituted dimethyl 3,9-dioxo-l,5,7,ll-tetrahydro-lA/,7A/-dipyrazolo l,2-a r,2 -<3 ][l,2,4,51tetrazine-l,7-dicarboxylates 124 <04T5319>. 

Methyl (S)-2-phthalimido-4-methylthiobutanoate 2H-lsoindole-2-acetic acid, 1,3-dihydro-a-[2-(methylthio)ethyll-1,3-dioxo-, methyl ester, (S)- (9) (39739-05-4) L-Methionine methyl ester hydrochloride Methionine, methyl ester, hydrochloride, L-(8) L-Methionine, methyl ester, hydrochloride (9) (2491-18-1)... 

Carminic acid (7-a-D-glucopyranosyl-9,10-dihydro-3,5,6,8-tetrahydroxy-l-methyl-9,10-dioxo-2-anthracene carboxylic acid. Neutral Red 4 Cl 75470) [1260-17-9] M 492.4, m... 

In agreement with the results of Cattelain, further methylation of the 3-methylmercapto derivative (96) results practically exclusively in 2-methyl-3-methylmercapto-5-oxo-2,5-dihydro-l,2,4-triazine (97). Further methylation of 5-methylmercapto derivative (90) yields 2-methyl-5-methylmercapto-3-oxo-2,3-dihydro-l,2,4-triazine (100). Their structure was confirmed by acid hydrolysis leading to 2-methyl-3,5-dioxo derivatives (62), As was already mentioned, this reaction is a suitable general procedure for preparing the 1-alkyl derivatives of 6-azauracil. ... 

Dioxo derivatives of 474 are known, " as well as 5-chloro-1,2-dihydro-1 -methyl-3-oxo-l,2,4,6,8-pentaazanaphthalene. ... 

When, aiming at its cardiotonic activity (stimulant), the 2,5-dioxo-l,2,5,6,7,8-hexahydro-3-cyano-6-bromoquinoline is made to react with different thioamides, the appropriate 6-substituted 8,9-dihydro- (R = cyanomethyl-, 2-oxopyrrolidinyl-methyl-, 2-oxohexahydroazepinomethyl-, and thioxopyrrolidinylmethyl-) (94KFZ43) or (R = H, Me, NH2, NH/S ) (86JAP(K)1, 89H1517) thiazolo[4,5-/Iquinolines 37 or oxidized products (89H1517) are produced. 

Amino acid abbreviations aa, generic amino acid Ala, L-alanine Aib, 2-aminoisobutyric acid Cys, L-cysteine Asp, L-aspartic acid Glu, L-glutamic acid Gly, glycine Lys, L-ly-sine Ser, L-serine Trp, L-tryptophan Ser, 2-amino-3-(5-methyl-2,4-dioxo-3,4-dihydro-2H-... 

Methyl 6-methyl-7-nitro-2,3-dioxo-l,2,3,4-tetrahydro-5-quinoxalinecarboxylate Methyl 4-methyl-3-oxo-3,4-dihydro-2-quinoxalinecarboxylate 2-Methyl-3-( 1 -methylprop-1 -enyl)quinoxaline Methyl 3-methyl-2-quinoxalinecarboxylate... 

The crystal structure of the 1-methyl-2,7-dioxo-2,3-dihydro-l//,7//-pyrido[3,2,l-y]cinnoline-8-carboxylate 22 was determined by means of an X-ray diffraction investigation <1995T11125>. In this case, the 1-methyl group is almost coplanar with the 4-oxoquinoline moiety. X-Ray investigations on l-methyl-7-oxo-2,3-dihydro-l//,7//-pyrido[3,2,l-y]cinnoline-8-carboxylate 23 revealed that 1-methyl group is perpendicular to the plane of the 4-quinolone moiety <1996BCJ1371>. 

Methyl 3-acyl-l-diphenylmethyleneamino-4,5-dioxo-4,5-dihydro-l//-pyrrole-2-carboxylates 489 are formed from 488 and oxalyl chloride in good yields. Preparative thermolysis of these compounds at 130-140°C gives mixtures of dipyrazolo[l,2- l,2- [l,2,4,5]tetrazines 491 as major products and pyrazoles 492 as minor hydrolytic by-products. The intermediacy of mesoionic compound 490 is expected (Scheme 83) <2004T5319>. 

NN/N 5-[(l,4-Dihydro-l,4-dioxo-3-(phenylamino)-2-(naphthalenyl)sulfonyl]-3-methyl-6-phenyl-5//-... 

The reaction of 2-anilino-l,4-naphthoquinone 374 with benzoylacetic acid hydrazide gives 3-hydrazino-pyrazolyl derivative 375, that is acetylated to produce 5-[[l,4-dihydro-l,4-dioxo-3-(phenylamino)-2-naphthalenyl]sulfonyl]-3-methyl-6-phenyl-5/7-pyrazolo[5,l-c][l,2,4]triazole 51. This latter derivative is also obtained in 51% yield from reaction of 374 with benzoylacetic acid hydrazide in the presence of a mixture of acetic acid-sodium acetate <2004PS(179)1907> (Scheme 39). 

This paper traces in some detail the path which led to the discovery of a new class of herbicides, the 2-(5-oxo-2-imidazolin-2-yl)arylcarboxylates. The journey started when it was found that a phthalimide, a-isopropyl-a-methyl-l,3-dioxo-2-isoindoline-acetamide, had sufficient herbicidal activity to warrant further synthesis effort. This work led to a series of analogs essentially devoid of herbicidal activity yet possessing interesting plant growth regulating effects. Further chemical modifications resulted in the synthesis of two new groups of compounds, imidazoisoindolediones and dihydro-imidazoisoindolediones, and the return of herbicidal activity. The imidazoisoindolediones were in turn transformed into o-(5-oxo-imidazo-lin-2-yl)benzoates, the first members of a very interesting new class of herbicides. 

The crystal structure of ethyl 4-(4-rert-butoxycarbonyl-l-piperazinyl)-5-fluoro-2,3-dihydro-l-methyl-2,7-dioxo-l//,7//-pyrido[3,2,l-iy]cinnoline-8-carboxylate (186, R = Et, R = tert-Qu, R = 4-tm-butoxycarbonyl-l-piperazinyl) was determined by means of X-ray diffraction investigation [95T11125]. 

Ceftriaxone Ceftriaxone, 7-[[(2-amino-4-lhiazolyl)-2-(Z)-(methyoximino)acetyl]amino]-8-oxo-3-[[(l,2,5,6-tetrahydro-2-methyl-5,6-dioxo-l,2,4-triazin-3-yl)thio]methyl]-5-thia-l-azabicyclo[4.2.0]oct-2-en-2-carboxylic acid (32.1.2.72), is synthesized by acylating 7-amino-3-[[(2,5-dihydro-6-hydroxy-2-methyl-l,2,4-triazin-5-on-3-yl)thio]methyl]3-cefem-... 

Phosphonic acid, [(1,3-dihydro-l,3-dioxo-2H-isoindol-2-yl)methyl]-, diethyl ester, 65, 119... 

Cycloaddition of dimethyl l,2,4,5-tetrazine-3,6-dicarboxylate with EWG-substituted primary ketene N,0-acetals provides a tetrasubstituted pyridazine, methyl 4-amino-5,7-dioxo-6,7-dihydro-5/7-pyrrolo[3,4-4pyridazine-3-carboxylate <200681513>. 

Acylamino-2,4-dioxo-l,2,3,4-tetrahydro- bzw. 5-Acylamino-4-oxo-3,4-dihydro-pyrimidine werden durch Umsetzung mit ethanolischem Natriumhydroxid in Ausbeuten von 34-84% zu 4-Aminocarbonyl-5-methyl-imidazolen umgelagert437. 

DIETHYLPHOSPHONOMETHYL-2, 2-DIMETHYL-1.3-DI0XEN-4-0NE, 66, 194-196, 202 Diethyl phthalimidomethylphosphonate Phosphonic acid, (phthalimidomethyl)-, diethyl ester Phosphonic acid, [(1,3-dihydro-l, 3-dioxo-2H-isoindol-2-yl)-methyl]-, diethyl ester (33512-26-4), 65, 119 DIHYDR0JASM0NE, 65, 26... 

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