Dinitropyrene

Figure 13 Chromatogram of an airborne particulate sample. Peaks 1 = 1,6-dinitropyr-ene 2 = 1,8-dinitropyrene 3 = 1,3-dinitropyrene 4 = 2-fluoro-7-nitrofluorene 5 = 1-nitropyrene. (From Ref. 60.)...

The human cell mutagenicities of several mono- and dinitropyrenes were determined by Busby and coworkers (1994b) in a forward mutation assay using a metabolically competent line of MCL-5 cells. Minimum detectable mutagen concentrations (MMC, in nmol ml-1 the smaller the detectable concentration, the greater the potency) were as follows 1,6-dinitropyrene, 0.8 1,8-dinitropyrene, 1.5 4-nitropyrene, 3.1 1-nitro-pyrene, 9.1. Other PACs tested, 2-nitropyrene, 1,3-dinitropyrene, and pyrene, were nonmutagens in this... 

Initially, major attention was focused on emissions of diesel soot from light- and heavy-duty motor vehicles, because the particle extracts contained such direct-acting bacterial mutagens and animal and possible human carcinogens (IARC Group 2B, 1989) as 1-nitropyrene (1-N02-PY) and the 1,6- and 1,8-dinitropyrenes (DNP), as well as a third isomer, 1,3-dinitropyrene, IARC Group III. For example, Paputa-Peck and coworkers (Paputa-Peck et al., 1983 IARC, 1989) reported 100 nitro-PAHs (17 positively identified) in... 

Nitrated polycyclic aromatic hydrocarbons, such as 1-nitropyrene, 1-nitrosopyr-ene and 1,3-dinitropyrene, have been measured in car exhaust deposits by HPLC with chemiluminescence detection after on-line EC reduction (PGEs, —1.6 V vs Pd)." LoDs of fmol on-column were claimed. 

Clostridium leptum C. paraputrificum C. clostridiiforme Eubacterium sp. 1 -nitropyrene 1,3-dinitropyrene 1,6-dinitropyrene Rafii et al. (40)... 

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