Dimethylethyl amine

The submitters used 2-(diphenylmet,hoxy)-A, IV-dimethylethyl-amine, b.p. 150-165° (2 mm.).2 This amine was obtained from Searle Chemicals, Inc. It is readily obtained from the hydrochloride, m.p. 161-162°, which is available commercially from Gane s Chemical Works, Inc., New York, N.Y., under the generic name, diphenhydramine. 

Subsequently, we examined several MFA derivatives as substrates for the Pt/C>2 reaction. When 32 was subjected to Pt/(>2 chemistry, three products (132-134) were isolated in poor yield [Fig. (36)]. In the case of 23, the Pt/C>2 reaction mixture was treated straightaway with m-CPBA without isolation of any intermediate products, giving the desired compound 10 (43% yield). Compound 10 can be converted to PHA (2) in three steps. Compound 132 was converted to PHA (2) by treatment with alane-dimethylethyl amine complex in THF (30% yield). 

We have recently reported an alternative liquid precursor for the CVD of aluminum thin films.3 The main advantage of (AT,AT-dimethylethanamine)-trihydridoaluminum, frequently referred to by its trivial name dimethylethyl-amine alane (DMEAA), over (trimethylamine) trihydridoaluminum is that DMEAA is a liquid at room temperature, which provides stationary pressure conditions for better control of precursor transport. Analogous to the previously reported synthesis of (trimethylamine)trihydridoaluminum,4 the reaction of lithium tetrahydroaluminate(l —) with AT,AT-dimethyl-ethanaminium chloride in diethyl ether generates the stable liquid precursor DMEAA with high yield. 

Di-/(-methylenebis(methylpentamethylcyclopentadienyl)dirhodium, 3849 (7/,7/-Dimethylethanamine)trihydroaluminium, see Alane—/V,/V-dimethylethyl-amine, 0071... 

The influence of sodium dodec3d sulfate, hexadecyltrimethyl-ammonium bromide and a polyoxyethylene(18) dodecylphenol on the hydrolysis of the Schiff bases p-chlorobenzylidene-l,l-dimethylethyl-amine, p-methoxybenzylidene-l,l-dimethylethylamme, and benz-hydrilidenedimethylammonium iodide (iV,iV-dimethylbenzophenone-imonium iodide) have been investigated (Behme and Cordes, 1965). The observed pseudo-first order rate constant for the hydrolysis ofp-chloro-... 

SYNS AMOSYT ANAUTINE ANDRAMINE AVIOMARIN o-BENZHYDRYLDIMETHYLAMINO-ETHANOL-8-CHLOROTHEOPHYLLINATE 2-(BENZHYDRYLOXY)-N,N-DIMETHYLETHYL.AMINE with 8-CHLOROTHEOPHYLLINE CHLORANAUTINE DIAiMARIN DIMENHYDRINATE DIPHEN-HYDRINATE DRAMAMIN DRAMARIN ... 

For perhaps 20% of the most polar small druglike molecules, either the peak does not elute or it elutes with severe distortion. The addition of a third component, usually a strong acid or base, alleviates this problem, as shown in Fig. 6. Ion pairing does not work. Ionization suppression seems to be a major mechanism in SFC. To improve the peak shapes of strong bases, another strong base (like dimethylethyl amine) is added. Similarly, to elute a strong acid, another strong acid (like TFA) is added (1). 

The change in rate-determining step from carbinolamine dehydration to carbinol amine formation occurs as the pH decreases [5,8,9]. As shown in Fig. 1 for the hydrolysis of substituted benzylidene-l,l-dimethylethyl amines, the pH rate profiles vary dramatically at lower pH values. The high pH rates are due to attack of hydroxide ion on protonated imine, which is the reverse of the dehydration of carbinolamine. At lower pH values the term due to water addition to protonated imine becomes substantial for those imines with electron withdrawing substituents. At even lower pH values the rate drops because of the change in rate determining step to the decomposition of the carbinolamine intermediate, which is the reverse of carbinolamine formation. In those cases where the zwitterionic intermediate formed by amine addition to a carbonyl compound ( j in Scheme 1) is very unstable, the required proton-transfer steps (kh Scheme 1) may become rate-determining. This... 

---