4-dimethylaminophenyl methyl

Lissamine Green B l-[bis-(4,4 -dimethylaminophenyl)methyl]-2-hydroxynapbthalene-3,6-disulfonic acid sodium salt. Acid Green 50 [3087-16-9] M 576.6, m >200°(dec). Cl... 

Experimental Procedure19 for 4-bis(4-dimethylaminophenyl)methyl-2,6 dimethoxyphenol (55a). A mixture of syringaldehyde (5.46 g, 30 mmol, A.A-dimethylaniline (7.26 g, 60 mmol), urea (2.7 g), and concentrated sulfur ic acid (4.41 g) in isopropanol (100ml) was heated at 90°C under a nitrogen atmosphere for 24h. The reaction was cooled to room temperature and 40ml of water added followed by 50% NaOH until alkaline. The mixture was filtered and the residue washed with 200ml of cold water. The solid was recrystallized from ethanol and yielded 12.0g (97%), mp 136-138°C. 

The crude product was purified by column chromatography (w-pentane diethyl ether 1 1) immediately after isolation and dried under vacuum yielding (aS,a A)-l,l,-bis(a-A,A-dimethylaminophenyl-methyl)-(R,R)-l,l -bis(diphenylphosphino)-ferrocene (392 mg, 0.48 mmol, 45%) as a yellow solid (mp 245-246 °C). 

In the series NHR. CO. O. CgH. NMe all the members tried in which R is a methyl group were active, but when R is ethyl or hydrogen, miotic action is reduced or may even disappear, thus the p and m-dimethylaminophenyl esters of ethylcarbamic acid (R = C2H5) are inactive but the o-ester is active, indicating that activity is also influenced by the position and nature of the basic group. When the tertiary basic... 

Methyl-6-aminobenzoselenazole when treated with 3-penten-2-one gave by a simple Doebner-Miller type reaction the 2,7,8-trimethylselenazoloquinoline 43 in 18.6% yield, that is the angular product and not the linearly annelated one was formed. Its structure was confirmed by the coupling constant in proton NMR (71JHC693). Selenazoloquinoline 43 can be converted via the 6-methylpyridium salt in the reaction with 4-dimethylaminobenzaldehyde to 2,6-dimethyl-7,9-bis(l-(4-dimethylaminophenyl)-2-ethenyl)selenazolo[5,4-/]quinolinium iodide 44 (Ar = 4-dimethylaminophenyl). This dye exhibited two absorption maxima between 500 and 600 nm (72MI2). 

Quinoxaline-2,3-dione is converted into 2,3-dichloroquinoxaline by phosphoryl chloride142 or phosphorus pentachloride.143 2,3-Dibromo-quinoxaline is similarly obtained using phosphoryl bromide in dimethyl-aniline.144 Quinoxalin-2-one undergoes ring contraction to 2-methyl-benzimidazole (134) with hydrazine145 however, quinoxaline-2,3-dione gives 3-hydrazino-2-quinoxalinone.145 Quinoxalin-2-one yields a 3-p-dimethylaminophenyl derivative with 7V,N-dimethylaniline (in AcOH, with NH4N03), and a 3-(indol-3-yl) derivative with indole.146... 

Antiprogestins, such as RU-486 (lift-hydroxy-11/3 (4 dimethylamino phenyl-1 )-17ry-(prop-l-ynyl)-estra-4.9-diene-3-one) (33) and ZK98299 1 l/J-(4-dimethylaminophenyl)-17a-hydroxy-17/j-(3-hydroxypropyl-13a-methyl-4,9-gonadien-3-one) represent a new class of drags for fertility regulation. Also, these drugs have potential applications in the treatment of uterine cancer. 

Ethoxy-7-methoxy-2-methyl-l-benzotellurinium fluorosulfate reacted with 4-dimethyl-aminobenzaldehyde to form 2-[2-(4-dimethylaminophenyl)-ethenyl]-4-ethoxy-7-methoxy-1-benzolellurinium fluorosulfate1. 

Dimethylaminophenyl)-ethenyl]]-4-ethoxy-7-methoxy-l-benzotellurmiuni Fluorosulfate1 0.30 g (2.0 mmol) of4-dimethylaminobenzaldehyde are added to 0.43 g(1.0 mmol) of4-ethoxy-7-methoxy-2-methyl-l-benzotellurinium fluorosulfate in 3 ml] of acetic anhydride and the mixture is heated on a steam bath for 2 min. The resultant mixture is then cooled to 0°, and the green solid is collected and recrystallized from acetonitrile yield 0.33 g (59%) m.p. 163-167°. 

The [2+2] cycloaddition reaction of isothiocyanates with carbodiimides generally proceeds across the C=S bond of the isothiocyanate to give thiazetidine derivatives 218. However, in the reaction of methyl isothiocyanate with N-(4-dimethylaminophenyl)-N -methylcarbodiimide a mixture of the thiazetidine derivative 218 and the isomeric iminodi-azetidinethione derivative 219 is obtained. The structure of 219 was confirmed by X-ray crystallography. ... 

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