Dimethylamino acetate

R = R = H, R = -0CH2CH20H), and the hydroxy group then was acylated with 2-(dimethylamino)acetic acid in CH2CI2 in the presence of 1,3-dicyclohexylcarbodiimide and 4-(dimethylamino)pyridine at room temperature (94EUP626378, 95USP5378720). 

As shown in Scheme 4.3, the Fisher indolization was thought to involve (i) hydrolysis of diethyl dimethylamino acetal 11, (ii) formation ofhydrazone 22, (iii) isomerization ofhydrazone to me-hydrazine 23, and (iv) [3.3] sigmatropic rearrangement followed by ring closure to give indole 16b. Acetal 11 is stable in AcOH at room temperature, but can be readily hydrolyzed to aldehyde 19 at 100 °C, with subsequent cyclization to hemiaminal 20. Hemiaminal 20 was also formed readily... 

Alkazid A development of the Alkacid proces. The absorbent is an aqueous solution of the potassium salt of either methylamino propionic acid ( Alkazid M ), or dimethylamino acetic acid ( Alkazid DIK ). Developed by Davy Powergas, Germany. Over 80 plants were operating in 1975. 

Additional semipermeable membrane—forming polymers are selected from the group consisting of acetaldehyde dimethyl cellulose acetate, cellulose acetate ethyl carbamate, cellulose dimethylamino acetate, semipermeable polyamides, semipermeable polyurethanes, or semipermeable sulfonated polystyrenes. Semipermeable cross-linked selectively permeable polymers formed by coprecipitation of a polyanion and a polycation also can be used for this purpose.22 23 Other polymer materials such as lightly cross-linked polystyrene derivatives, semipermeable cross-linked poly(sodium styrene sulfonate), and semipermeable poly (vinylbenzyltrimethyl ammonium chloride) may be considered.24,25... 

Penetration enhancers such as azone and dodecyl N, A-dimethylamino-acetate appear to increase the skin s impedance [13]. The authors speculate that this may be related to the fact that these enhancers increase the skin s heterogeneity (as assessed, in part, by an observed increase in the skin s... 

An efficient one-pot, three-component synthesis of substituted 1,2,4-triazoles 164 has been reported from primary amines 161, dimethylamino acetals 162, and acyl hydrazides 163 <04OL2969>. 1,3-Benzoxazine 165 reacted with acyl hydrazides in refluxing methanol to give... 

Flecker, C., Wong, O., and Rytting, J.H. (1989). Facilitated transport of basic and acidic drugs in solutions through snakeskin by a new enhancer-dodecyl A,A-dimethylamino acetate, Pharmaceutical Research, 6 443-448. 

A mixture of n butyl 8-chlorol,2a,3j, 9,9aa, 10-hexahyd o-3,4-dihyd oxy-5-methoxy-10-oxoanth acene-2-(a-dimethylamino)acetate hydrochloride and half its weight of p-toluenesulfonic acid in toluene stirred and refluxed 3 hrs. under with azeotropic water entrainment 6-chloro-3-dimethylamino-ll-hydroxy-3aformic acid, Zn-dust added, vigorously swirled, and the product isolated after 1 min. 8 - chloro-1,2a, 3,9,9aa, 10 -hexahydr o-4-hy droxy-5-methoxy- 10-oxoanthracene -2-(a-dimethylamino)acetic acid (Y 81%, methanol-solvated). - This is part of a total synthesis of dl-6-demethyl-6-deoxytetracycline. J. J. Korst et al.. Am. Soc. 90, 439 (1968). 

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