Dimethylamino acetic acid

R = R = H, R = -0CH2CH20H), and the hydroxy group then was acylated with 2-(dimethylamino)acetic acid in CH2CI2 in the presence of 1,3-dicyclohexylcarbodiimide and 4-(dimethylamino)pyridine at room temperature (94EUP626378, 95USP5378720). 

Alkazid A development of the Alkacid proces. The absorbent is an aqueous solution of the potassium salt of either methylamino propionic acid ( Alkazid M ), or dimethylamino acetic acid ( Alkazid DIK ). Developed by Davy Powergas, Germany. Over 80 plants were operating in 1975. 

A mixture of n butyl 8-chlorol,2a,3j, 9,9aa, 10-hexahyd o-3,4-dihyd oxy-5-methoxy-10-oxoanth acene-2-(a-dimethylamino)acetate hydrochloride and half its weight of p-toluenesulfonic acid in toluene stirred and refluxed 3 hrs. under with azeotropic water entrainment 6-chloro-3-dimethylamino-ll-hydroxy-3aformic acid, Zn-dust added, vigorously swirled, and the product isolated after 1 min. 8 - chloro-1,2a, 3,9,9aa, 10 -hexahydr o-4-hy droxy-5-methoxy- 10-oxoanthracene -2-(a-dimethylamino)acetic acid (Y 81%, methanol-solvated). - This is part of a total synthesis of dl-6-demethyl-6-deoxytetracycline. J. J. Korst et al.. Am. Soc. 90, 439 (1968). 

Ferrocene (46.4 g., 0.250 mole) (Note 1) is added to a well-stirred solution of 43.2 g. (0.422 mole) of bis(dimethylamino)-methane (Note 2) and 43.2 g. of phosphoric acid in 400 ml. of acetic acid in a 2-1. three-necked round-bottomed flask equipped with a condenser, a nitrogen inlet, and a mechanical stirrer (Note 3). The resulting suspension is heated on a steam bath under a slow stream of nitrogen (Note 4) for 5 hours (Note 5). The reaction mixture, a dark-amber solution, is allowed to cool to room temperature and is diluted with 550 ml. of water. The unreacted ferrocene is removed by extracting the solution with three 325-ml. jiortions of ether. The aqueous solution is then looled in ice water and made alkaline by the addition of 245 g. 

This has been confirmed by Spath and Lorenz, who have shown that dihydro-0-conhydrinemethine must be a-dimethylamino-octan-j8-ol, MejN. CHj. CHOH. CHa. (CHa). CHj, since it is oxidised by chromic acid in acetic acid to a-dimethylamino-octan-(3-one, which has been synthesised from w-heptoylchloride by the action of diazomethane in ether, and treatment of the resulting a-chloro-w-octan-(3-one with dimethylamine. 

Chemical Name a-(1-hydroxycyclopentyl)benzene-acetic acid 2-(dimethylamino)ethyl ester hydrochloride... 

Spray solution 2 Dissolve 0.5 g 4-(dimethylamino)-benzaldehyde in a mixture of 50 ml ethanol and 50 ml glacial acetic acid. 

In a first step oxidized aromatic amines are reduced with titanium(III) chloride in glacial acetic acid solution and then condensed to a colored Schiff s base with 4-(dimethylamino)-benzaldehyde (cf. Chapter 2). 

Dimethylamino)-benzaldehyde-Acetic Acid-Phosphoric Acid Reagent... 

Dissolve 0.25 g 4-(dimethylamino)-benzaldehyde in 50 ml glacis acetic acid and add 3 ml ortAo-phosphoric acid (85< o) [10]. 

In this instance I should be a relatively strong base in glacial acetic acid, e.g., p,p -bis(dimethylamino)azobenzene, and its K] and K must be previously determined hence, according to reaction 4.58, eqns. 4.59 and 4.60 yield... 

The synthesis of the furan-imidazole derivatives, shown in Scheme 2, were also described by Wang et al. [34]. Reaction of 4-(dimethylamino)benzalde-hyde (20) with trimethylsilylcyanide (TMS)-CN in the presence of Znl2 produced the TMS cyanohydrin 21. Compound 21 was treated with LDA followed by the addition of 3,4,5-trimethoxybenzaldehyde to give the benzoin intermediate 22. Oxidation with CUSO4 in aqueous pyridine, followed by reaction with 3-furaldehyde in acetic acid, produced the substituted imidazole 23. 

In its reaction with aniline, 43a reveals its enaminoketone properties The presence of small quantities of acetic acid initiates an addition/elimina-tion reaction in which the dimethylamino is displaced by the phenylamino group yielding 44 at 72%. 

With boron trifluoride-etherate, methanethiol and acetic acid fluorine is incorporated in almost quantitative yields. For example, the bis-dimethylamino-derivative 164 can be converted to l-fluoro-l-dimethylamino-2.4.6-triphenyl-phoshorin 172. ... 

Reaction of the ketosulfone (ix) with 2-chloro-1,3-bis(dimethylamino)trimethinium salt (xix) in the presence of an equimolar amount of tert-BuOK followed by treatment with acetic acid and TFA and reflux with an excess of ammonium hydroxide. 2-Chloro-1,3-bis(dimethylamino)trimethinium hexafluoro-phosphat (xix) is obtained by reaction of chloroacetic acid with hot dimethylformamide and POCI3. Finally the reaction mixture is treated with NaOH and hexafluorophosphoric acid in water. 

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