Dimethylamine chloride

If the metlijlainiiie hydrochloride in solution from the previous re.action be heated with a further quantity of formalin at 115° dimethylamine hydrochloride (dimethylammonium chloride) may be isolated ... 

OleFns and Fatty Alcohols. Alkylbenzyldimethylammonium (ABDM) quatematies are usually prepared from a-olefin or fatty alcohol precursors. Manufacturers that start from the fatty alcohol usually prefer to prepare the intermediate alkyldimethylamine direcdy by using dimethylamine and a catalyst rather than from fatty alkyl chloride. Small volumes of dialkyldimethyl and alkyltrimethyl quatematies in the Cg—range are also manufactured from these precursors (Fig. 4). 

Methyl chloride reacts with ammonia alcohoHc solution or ia the vapor phase by the Hofmann reaction to form a mixture of the hydrochlorides of methylamine, dimethylamine, trimethyl amine, and tetramethyl ammonium chloride. With tertiary amines, methyl chloride forms quaternary derivatives. 

Diethyl aniline, 54 Diethylcarbaniazine citrate, 54 Diethyl carbamyl chloride, 54 Diethyl chlorophosphate, 54 Diethylene triamine, 54 Diethyl ether, 54 Di(2-ethylhexyl) phthalate, 54 Diethyl ketone, 54 Diethyl-p-phenylenediamine, 54 Diethyl phthalate, 54 Diethylstilbestrol, 55 Diethyl sulfate, 55 Diethyl zinc, 55 Difluoromethane chloride, 55 Digitoxin, 55 Diglycidyl ether, 55 Digoxin, 55 Diisobutyl ketone, 55 Diisopropylamine, 55 Diisopropyl ether, 55 DIKAMIN , 2,4-D, 55 DIKONIRT , 2,4-D, 55 Dimefox, 55 Dimethoate, 55 3,3 -Dimethoxybenzidine, 55 n,n-Dimethylacetamide, 56 Dimethylamine, 56 4-Dimethylaminoazobenzene, 56 Dimethylaminoethanol, 56 n,n-Dimethyl aniline, 56 7,12-Dimethylbenz[a]anthracene, 56 3,3 -Dimethylbenzidine, 56... 

Condensation of ethyl acetoacetate with phenyl hydrazine gives the pyrazolone, 58. Methylation by means of methyl iodide affords the prototype of this series, antipyrine (59). Reaction of that compound with nitrous acid gives the product of substitution at the only available position, the nitroso derivative (60) reduction affords another antiinflammatory agent, aminopyrine (61). Reductive alkylation of 61 with acetone in the presence of hydrogen and platinum gives isopyrine (62). Acylation of 61 with the acid chloride from nicotinic acid affords nifenazone (63). Acylation of 61 with 2-chloropropionyl chloride gives the amide, 64 displacement of the halogen with dimethylamine leads to aminopropylon (65). ... 

Some alicyclic 1,2-diamine derivatives have recently been shown to have interesting CNS properties. For example, eclanamine (34) is an antidepressant with a rapid onset of action. The reasons for its potency are not as yet clear but pharmacologists note that the drug desensitizes adrenergic alpha-2 receptors and antagonizes the actions of clonidine. The synthesis of eclanamine starts with attack of cyclopentene oxide (30) by dimethylamine (to give 31). This product is converted to the mesylate by reaction with sodium hydride followed by mesyl chloride. Attack of... 

First, dimethylamino-2-phenoxyethane was made by reacting chloro-2-phenoxyethane with dimethylamine. Benzyl chloride (10 grams) was then added to a solution of 1-dimethylamino-2-phenoxyethane (12.3 grams) in acetone (35 ml). The mixture warmed spontaneously and N-benzyl-N,N-dimethyl-N-2-phenoxyethylammonium chloride slowly crystallized. After 24 hours, this solid was filtered off, washed with fresh acetone and dried immediately in vacuo, MP 135°-136°C. 

Dimethy/su/famy/thioxanthene To a slurry of dry sodium thioxanthene-2-sulfonate (33.3 grams, 0.111 mol) in 50 ml of N,N-dimethylformamide was added thionyl chloride (14.3 grams, 0.122 mol) in divided portions. An exothermic reaction ensued with complete dissolution being effected in minutes. Treatment of the reaction mixture with crushed ice precipitated a gum which crystallized after a short period of stirring. The sulfonyl chloride was filtered, washed with water, and stirred with 100 ml of liquid dimethylamine. 

C19H33CI 4860-03-1) see Cetalkoniura chloride Cetylpyridinium chloride A -cetyl-Af,A-dimethylamine... 

This fluorescent acid chloride can be used to form derivatives of alcohols, amines, and phenols. Using these fluorescent derivatives, an analysis of a series of n-alcohols from Ci to C4 was developed. A chromatogram produced by this technique is shown in Figure 3. Derivatives were also formed from ammonia, dimethylamine, and phenol. A derivative was formed from pentachlorophenol but was not fully characterized. The quantum yields of fluorescence of the alcohol derivatives of V were lower than those of the alkyl halide derivatives of III. 

N,N-Dimethylcyclohexanecarboxamide has been prepared by acylation of dimethylamine with cyclohexanccarbonyl chloride ... 

The scheme used to prepare the direct 8-aza-analogue 21 of estrone bears at least formal similarity to the Torgov-Smith steroid total synthesis sequence. Acylation of the phenethylamine 9 with acryloyl chloride gives amide 16. Michael addition of dimethylamine followed by Bischler-Napieralski cyclodehydration gives the dihydroisoquinoline, 17. 

The use of phenylpiperidinols rather than the meperidine-related piperidines as the basic component in antidiarrheal compounds results in retention of activity. The fact that the base is not directly related to a narcotic presumably leads to greater selectivity of action on the gut. Ring scission of butyrolactone 98 (obtainable by alkylation of a diphenylacetate ester with ethylene oxide) with hydrogen bromide gives the bromo acid 99. This is then converted to the dimethylamide by successive treatment with thionyl chloride and dimethylamine. 

CENTRAL RING CONTAINING ONE HETEROATOM Reaction of 2-bromobenzoic acid (1) with chloroSulfonic acid proceeds to afford the sulfonyl chloride 2 treatment with dimethylamine leads to the corresponding sulfonamide (3). Condensation of bromoacid 3 with the anion from thiophenol in the presence of copper powder results in displacement of halogen by sulfur... 

The chlorides 73a and 73b on reacting with dimethylamine in benzene afforded the amidates 92 and 93 respectively with complete diastereoselectivity. [58] The diastero-meric amides 94-96 were prepared in a similar manner by reacting 73a with chiral primary amines (optically active or racemic) and the isolated amides were applied for quantification of enantiomeric excesses of the amines of interest (Scheme 27) [55], A similar reaction with 1,2-diaminoethane gave bisphosphoramide 98 [59],... 

A 2-1. three-necked flask is equipped with a stirrer, a 500-ml. dropping funnel protected by a calcium chloride drying tube, and a reflux condenser topped with a potassium hydroxide drying tube. The reaction vessel is cooled in an ice-salt bath and is charged with 500 ml. of dry pentane and 293 g. (6.5 mols) of anhydrous dimethylamine. A solution of 117.2 g. (1 mol) of boron trichloride in 400 ml. of pentane, prepared by passing the gaseous chloride into chilled pentane, is added slowly with... 

N-(2- [Ethoxy(methyl)phosphoryl]sulfanyl ethyl)-IV-isopropyl-N-methylpropan-2-aminium Iodide N-(2- [Ethoxy(methyl)phosphoryl]sulfanyl ethyl)-IV-isopropylpropan-2-aminium Chloride N-(2-Chloroethyl)dimethylamine N-(2-Chloroethyl)-N,N-dimethylamine N-(2-Hydroxyethyl)diethylamine N-(4-Oxy-3-methoxybenzyl)-8-methyl-6-nonenamide N-(Diethylamino)ethanol N-(Isopropyl)-2-propamine... 

The Sonogashira reaction is of considerable value in heterocyclic synthesis. It has been conducted on the pyrazine ring of quinoxaline and the resulting alkynyl- and dialkynyl-quinoxalines were subsequently utilized to synthesize condensed quinoxalines [52-55], Ames et al. prepared unsymmetrical diynes from 2,3-dichloroquinoxalines. Thus, condensation of 2-chloroquinoxaline (93) with an excess of phenylacetylene furnished 2-phenylethynylquinoxaline (94). Displacement of the chloride with the amine also occurred when the condensation was carried out in the presence of diethylamine. Treatment of 94 with a large excess of aqueous dimethylamine led to ketone 95 that exists predominantly in the intramolecularly hydrogen-bonded enol form 96. 

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