2,2 -Dimethyl-7 -hydroxy -5-methy

Dimethyl 4-hydroxy methy 1-1 3-dioxolane Sodium hydride Hydrogen chloride... 

BU-diitt8tlwlamino-3.3 -dimethyl-d ipheny Imethan-biS hydroxy methy lat 18183. 

Bis- 3-(bzw.4)-[2,2-dimethyl-2-(2-hydroxy-propyl)-1 -dehydro-hydrazinocarbonyl]-phenyl - 687 Bis-[2-methy]-phenyl]- 538 -bis-phosphonsaure-diester 523 Bis-[trifluormethy]]- 538 tert.-Butyl-( 1-hydroperoxy-cyclopentyl)- 571 tert.-Butyl-( 1 -hydroxy-cyclopentyl)- 571 (4-Chlor-phenyl)-(2-nitro-phenyl)- 693 (4-Chlor-phenylthio)-(4-nitro-phenyl)- 700 [Cyclohexen-(l)-yl]-phenyl- 368 Diaryl- 550, 552, 558, 567 Diphenyl-... 

Dihydro-7-hydroxy-2S, 3R -dimethyl-3-[4-methyl-5- (4-methy 1-2-furyl) -3(E)-pentenyl]-furo[3,2-C]coumarin Rt AOSZ... 

The other factor that may determine the type of cell death is the chemical structure of inducing agents [14]. We have recently found that u,(>-unsaluraled ketones such as 4,4-dimethyl-2-cyclopenten-l-one, a-methy-lene-y-butyrolactone, 5,6-dihydro-2H-pyran-2-one [15], codeinone [16], and morphinone [17] and a-hydroxylketones such as 3,3,3-trifluoro-2-hydroxy-1-phenyl-1-propanone induced caspase-independent cell death [18], induced vacuolization or autophagosome formation engulfing organelles, but without induction of apoptosis markers. 

FIGURE 8.8 Magnetic field dependence for the photolysis of a series of benzoyl containing molecules in cyclohexanol solution obtained by time-resolved infrared spectroscopy of the carbonyl group of the resulting benzoyl radical. Key 1 = a,a,a-trimethylacetophenone, 2 = 2-hydroxy-4-(2-hydroxyethoxy)-2-methylpropiophenone, 3 = 1-benzoylcyclohexanol, 4 = 2-hydroxy-2-methy Ipropiophenone, 5 = benzoin, 6 = methyl ether benzoin, 7 = dimethyl ether benzoin, 8 = 2-dimethylamino-2-(4-methyl-benzyl)-l-(4-morpholin-4-yl-phenyl)-butan-l-one. 

Cyclopropan 2,2-Dimethyl-1-hydroxy-3-methy lamino-1 -phenyl- E17a, 106 (3-Oxo-NHR/hv)... 

Dichloropyrazines have also been prepared from the corresponding hydroxy compounds as follows 2,3-dihydroxypyrazine with phosphoryl chloride containing pyridine (481, 757) [see Schneller and May (828) re the use of phenylphosphonic dichloride at 150-170°] 2,3-dihydroxypyrazine and its methyl, dimethyl, phenyl, diphenyl, and 5-methy 1-6-phenyl derivatives with phosphoryl chloride (483, 829) [N.B. error in work of Minovici and Bente (830)] 2-chloro-5-hydroxypyrazine with phosphoryl chloride (831) 2-chloro-6-hydroxypyrazine with phosphoryl chloride at reflux for 6hours (832) and 2,5-dihydroxy-3-phenylpyrazine and3,5-dihydroxy-2-phenylpyrazine with phosphoryl chloride at 180-200° (829). 

Carboxy-l-diisopropylaminocar-bonyl-1-methyl- 1358 2-Cyano-l-[(3,3-dimethyl-3-hydroxy-2-propy loxycarbonyl)-methy I]-1 -... 

Dihydroxy- 687 5.7- Dihydroxy-3-methy]- 687 1.3-Dimethyl-7-hydroxy-5-phenyI- 687 7-Hydroxy-5-mercapto-3-methyi- 687 4-Hydroxy-7-mercapto-2-methyl- 690 4-Hydroxy-2-methyl- 690... 

Carbonic acid, dimethyl ester 9.9 Pentanone-2,4-hydroxy-4-methy 1 9.2... 

Desoxypyridoxine Hydrochloride. 5-Hydroxy-4,6 dimethyl 3 pyridinemethaaot hydrochloride 2.4-dimeih-yl-3-Hydroxy-5-hyd roxy methy Ipy ridine hydrochl Oride 3-hydroxy-5-hydroxymethyl-2,4-dimethylpyridine hydrochloride 4-desoxyadermin hydrochloride. CsHj2Cl NO, mol Wl J89-64. C 50.66%, H 6.38%, CL 18.70%, N 7.39%. 6 16.87%. Synthesis starting with 3-cyano-4.6-dimethyl-2-pyridone Zima, Jung, Ger. pat, 707,266 (1941 to E. 

Fragmentation processes of photoinitiators form a number of volatile products, which may contribute to indoor air pollution. Benzaldehyde and alkyl-substituted benzalde-hydes are usual components, because Norrish-I is the most important reaction for cleavage. Awell known example is l-phenyl-2-hydroxy-2-methyl-propane-l-one (PHMP). a-Cleavage generates two radicals in the first step. The benzoyl radical may recombine to form benzil, reduction of PHMP leads to l-phenyl-2-methy 1-1,2-propane and acetone, and recombination of the 2-hydroxypropyl radical gives 2,3-dimethyl-2,3-butanediol... 

Serricorole [(25,3/ ,l 5,2 5)-2-ethyl-2,3-dihydro-6-(2-hydroxy-1 -methy lbutyl)-3,5-dimethyl-4//-pyran-... 

Bidwillon B, B-10022 1 -[2,4-Dihydroxy-3-( 3-methy 1-2-buteny 1) phenyl]-3-(8-hydroxy-2,2-dimethy 1-2//-1 -benzopyran-6-yI)-2-propen-1 -one, D-30198 2-(2,4-Dihydroxyphenyl)-8,8-dimethyl-10-(3-methyl-2-butenyl)-8//-pyrano[2,3-rf) chroman-4-one, D-10234... 

Obtained by successively adding an aqueous solution of sodium bicarbonate (6 mmol), then tetrakis(triphenyl-phosphine)palladium (0) (0.1 mmol) to a solution of 3-bromo-2-hydroxy-5-methy-lacetophenone (2 mmol) and phenylboronic acid (2 mmol) in ethylene glycol dimethyl ether (DME). After, the reaction mixture was refluxed for 10 min and then heated at 75° overnight (71%) (compound 26) [1804]. 

Obtained by partial methy-lation of 2,4-di-hydroxy-6-methoxy-3-ptenylphaiyl benzyl ketone with dimethyl sulfate in the presence of potassium carbonate in refluxing acetone for 3.5 h (96%) [5352]. 

Diethyl-2-hydroxypheny 1)-1 -propanone, 1890 l-(3,5-Diethyl-4-hydroxyphenyl)-l-propanone, 1890 1 -[2-( 1,1 -Dimethylethyl)-6-hydroxyphenyl]- 1-propanone, 1890 l-[3-(l,l-Dimethylethyl)-2-hydroxyphenyl]-l-propanone, 1891 l-[3-(l,l-Dimethylethyl)-4-hydroxyphenyl]-l-propanone, 1891 l-[4-(l. l-Dimethylethyl)-2-hydroxyphenyl]-l-propanone, 1891 l-[5-(l.l-Dimethylethyl)-2-hydroxyphenyl]-l-propanone, 1892 l-(2-Ethyl-3-methoxy-5-methylphenyl)-l-propanone, 1893 1 -(3 -Ethyl-4-methoxyphenyl)-2-methyl-1 -propanone, 2039 l-(2-Hydroxy-3,4-dimethylphenyl)-2,2-dimethyl-l-propanone, 2089 l-(2-Hydroxy-3,5-dimethylphenyl)-2,2-dimethyl-l-propanone, 2090 l-(2-Hydroxy-4,5-dimethylphenyl)-2,2-dimethyl-l-propanone, 2090 l-(4-Hydroxy-3,5-dimethylphenyl)-2,2-dimethyl-l-propanone, 2090 1 - [2-Hydroxy-5-(l -methy lethyl)phenyl]-2-methyl-1 -propanone, 2039 1 - [2-Hydroxy-3 -methyl-6-( 1 -methylethyl)phenyl]-1 -propanone, 1893 1 - [2-Hydroxy-4-methyl-3-( 1 -methylethyl)phenyl]-1 -propanone, 1893 1 - [2-Hydroxy-4-methyl-5-( 1 -methylethyl)phenyl]-1 -propanone, 1894 1 - [2-Hydroxy-5-methyl-3-( 1 -methylethyl)phenyl]-1 -propanone, 1894 1 - [2-Hydroxy-6-methyl-3-( 1 -methylethyl)phenyl]-1 -propanone, 1895 l-[2-Hydroxy-6-methyl-4-(l-methylethyl)phenyl]-l-propanone, 1895 l-[4-Hydroxy-2-methyl-3-(l-methylethyl)phenyl]-l-propanone, 1896 l-[4-Hydroxy-2-methyl-5-(l-methylethyl)phenyl]-l-propanone, 1896 l-[4-Hydroxy-5-methyl-2-(l-methylethyl)phenyl]-l-propanone, 1896 l-[6-Hydroxy-2-methyl-3-(l-methylethyl)phenyl]-l-propanone, 1897 l-[2-Hydroxy-5-(l-metliylpropyl)phenyl]-l-propanone, 1897 1 - [4-Hydroxy-3-( 1 -methy lpropyl)phenyl]-1 -propanone, 1897 l-(6-Hydroxy-2,3,4-trunethylphenyl)-2-methyl-l-propanone, 2039 l-(2-Methoxy-4,6-dimethylphenyl)-2-methyl-l-propanone, 2040 l-(4-Methoxy-3,5-dimethylphenyl)-2-methyl-l-propanone, 2040 l-(2-Methoxy-5-methylphenyl)-2,2-dimethyl-l-propanone, 2091 l-(2-Methoxy-6-methylphenyl)-2,2-dimethyl-l-propanone, 2091 l-(4-Methoxy-2-methylphenyl)-2,2-dimethyl-l-propanone, 2091 l-(4-Methoxy-3-methylphenyl)-2,2-dimethyl-l-propanone, 2092 l-(5-Methoxy-2-methylphenyl)-2,2-dimethyl-l-propanone, 2092 l-(4-Methoxy-2,3,5-trimethylphenyl)-l-propanone, 1898 l-(4-Methoxy-2,3,6-trimethylphenyl)-l-propanone, 1898... 

Isolated from the species Lyngbya semiplena collected at a shallow depth (1-3 m) in Wewak Bay, Papua New Guinea, the wewakpeptins A-D are cytotoxic depsipeptides which contain many nonribosomal amino acids such as 2,2-dimethyl-3-hydroxy-octanoic acid (Dhoaa) and 2,2-dimethyl-3-hydroxy-octynoic (Dhoya), as well as N-methy-lated amino adds such as N-methylvahne and N-methyl-alanine. A second lactone implies 2-hydroxy-isovaleric add (Hiva) for wewakpeptins A and B, and phenyllactic add (Pla) for wewakpeptins C and D. Wewakpeptins A and B are approximately tenfold more cytotoxic towards the lung cancer NCI-H460 than are wewakpeptins C and D (Han et al, 2005b). 

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