Dimethyl -aspartate

S)-Dimethyl aspartate hydrochloride was prepared as described3 and recrystallized from acetone to give a white crystalline solid (mp 114.5-115°C, lit.5 mp 116-117°C), which was stored in a vacuum desiccator before use. 

Bromo-9-phenylfluorene 9H-Fluorene, 9-bromo-9-phenyl (9) (55135-66-5) (S)-Dimethyl aspartate hydrochloride Aspartic add, dimethyl ester, hydrochloride, L- (8) L-Aspartic acid, dimethyl ester, hydrochloride (9) (32213-95-9) 9-Methoxy-9-phenylfluorene 9H-Fluorene, 9-methoxy-9-phenyl- (9) (56849-87-7) 9-Phenyl-9-fluorenol Fluoren-9-ol, 9-phenyl- (8) 9H-Fluoren-9-ol, 9-phenyl- (9) (25603-67-2)... 

A porphyrin host 67 having two hydrogen-bonding sites and a coordinating site was prepared for additional recognition of a polar side-chain.The porphyrin receptor 67 showed preference for amino-acid esters with a polar side-chain group, particularly dimethyl aspartate. The value of — AG for Asp(OMe)-OMe in CHCH was 27.6k.l/mol while that for Leu-OMe was 24,2 kJ/mol (Table 2, entry 120,121). 

L-Aspartic acid, N,N-dimethyl-. See Dimethyl aspartic acid... 

Dimantine. See Dimethyl stearamine DIMASPA. See Dimethyl aspartic acid Dimazin Dimazine. See 1,1-Dimethylhydrazine DIMDAC. See Dimethyl diallyl ammonium chloride... 

Dimethylarsinic acid sodium salt ((Dimethylarsino)oxy)sodium-as-oxide. See Sodium cacodylate Dimethyl aspartic acid CAS 1115-22-6... 

Dimethicone/sodium PG-propyIdimethicone thiosulfate copolymer Dimethiconol panthenol Dimethyl aspartic acid Dimethyl behenamine Dimethyl imidazolidinone Dimethyl myristamine Dimethyl palmitamine Dimethyl stearamine Dioctyl maleate ... 

When chirality is in the acyl donor, alcoholysis in neat alcohols can be used to shift the equilibrium to the product side. Successful regioselective and enan-tioselective alcoholysis of W-acylated dimethyl aspartate in neat -butanol with CAL-B (reaction A) and acylase I (reaction B) serve as good examples (Fig. 11) (17). 

DL-Aspartic acid dimethyl ester hydrochloride [14358-33-9] M 197,7, 116-117". Crystd from absolute MeOH. [Kovach et al. J Am Chem Soc 107 7360 1985.] Diethyl ester has pK 6.4. 

The -butyl ester is a relatively hindered ester, and many of the following methods for its formation should be, and in many cases are, equally effective for the preparation of other hindered esters. The related 1- and 2-adamantyl esters have been used for the protection of aspartic acid and other amino acids (1-AdOH, toluene, dimethyl sulfate, cat. TsOH, 70-80% yield). ... 

Dimethyl-3-pentanoL DCC, DMAP, CH2CI2, 4 h. This group was developed as an improvement over the use of cylcohexanol for aspartic acid protection during peptide synthesis. ... 

S)-N-(9-PHENYLFLUOREN-9-YL) ALANINE AND (S)-DIMETHYL N-(9-PHEN YLFLU0REN-9-YL)ASPARTATE L-Alanlne, N-(9-phenyl-9H-fluoren-9-yl)- and L-Aspartic acid, N-(9-phenyl-9H-fluoren-9-yl>, dimethyl ester)... 

Rao TS, Correa LD, Lloyd GK. (1997). Effects of lobeline and dimethyl-phenylpiperazinium iodide (DMPP) on N-methyl-D-aspartate (NMDA)-evoked acetylcholine release in vitro evidence for a lack of involvement of classical neuronal nicotinic acetylcholine receptors. Neuropharmacology. 36(1) 39-50. 

Dimethyl phosphorodithioic acid, see Malathion 0,0-Dimethyl phosphorophosphate, see Methoate Dimethyl phosphorothioate, see Malathion, Parathion 0,0-Dimethyl phosphorothioate, see Malathion 0,5-Dimethyl phosphorothioate, see Acephate Dimethyl phosphorothioic acid, see Dimethoate Dimethyl phosphorothionic acid, see Malathion 0,0-Dimethyl phosphorothionic acid, see Malathion Dimethyl sulfide, see Methyl mercaptan Dimethyl thiophosphate, see Malathion Dimethyl thiophosphoric acid, see Malathion Dimethyl triclopyr-aspartate, see Triclonvr Dimethyl triclopyr-glutamate, see Triclopvr... 

Plant. Fewer and Owen (1989) found 3,5,6-trichloro-2-pyridinol as the major metabolite in plants. Cultured soybean cells metabolized triclopyr to dimethyl triclopyr-aspartate and dimethyl triclopyrglutamate which can be rehydrolyzed to form the parent compound. 

A contemporaneous study on the same subject utilized a chemical correlation method where (—)-A-benzylargemonine chloride, obtained by sequential optical resolution and quatemization of ( )-7V-methylpavine (5), underwent a multistep degradative process to furnish (-)-A,A-dimethyl-di-H-propyl aspartate. Comparison of this final product with L-aspartic acid of known chirality led to the absolute configuration of (—)-5 (115,158). (—)-Eschscholtzine (9) was assigned the same absolute configuration by correlation of its ORD curve and optical rotation with those of (—)-argemonine (775). 

Alternatively, oxazolones have been used as reagents to activate and to couple N-protected dicarboxylic amino acids wherein the carboxylate moiety acts as the nucleophile. For example, 2,4-dimethyl-5(4//)-oxazolone 255 reacts with N-benzyloxycarbonyl-L-aspartic acid to give a mixture of the anhydrides 256 and 257. Subsequent reaction of 256 and 257 with phenylalanine methyl ester hydrochloride and A-methylmorpholine produces a mixture of the a-isomer 258 and p-isomer 259 of Al-benzyloxycarbonyl-aspartylphenylalanine methyl ester (Scheme 7.83). °... 

ATP, adenosine 5 -triphosphate BH4, 5,6,7,8-tetrahydrobiopterin BMPO, 5- er -butoxycarbonyl-5-pyrroline A-oxide DBNBS, 3,5-dibromo-4-nitrosoben-zene sulfonate DEPMPO, 5-diethoxyphosphoryl-5-methyl-l-pyrroline A-ox-ide DMPO, 5,5-dimethyl- 1-pyrroline A-oxide EMPO, 5-ethoxycarbonyl-5-methyl-l-pyrroline A-oxide GSH, glutathione (y-L-glutamyl-L-cysteinyl-glycine) HRP, horseradish peroxidase MNP, 2-methyl-2-nitrosopropane MPO, myeloperoxidase NAD(P)H, fl-nicotinamine adenine dinucleotide (3 -phosphate), reduced from NMDA, A-methyl-D-aspartic acid PBN, N-tert-butyl-a-phenylnitrone PMN, polymorphonuclear lymphocyte POBN, a-(4-pyridyl-l-oxide)-A-fer -butylnitrone SOD, superoxide dismutase TEMP,... 

Recently, studies of the conformation of oligomers were extended to peptides derived from /3-methyl-L-aspartates. Their synthesis (n = 2 up to 14) was described by Goodman and Boardman (82), and later the specific rotations of their solutions in dimethyl formamide, dichloro-acetic acid and in chloroform were determined (83). The oligomers exist in a random-coil form in the first two solvents, but helices become stable in chloroform for n — 11 and 14. These peptides are unusual since their L-amino-acid residues produce a left-hand helix (84, 85) whereas most of the investigated polyamino acids crystallise as a right-hand helix (86). 

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